Award Data

In this NASA Phase I STTR effort, the feasibility of fabricating isolated ridge waveguides in 5% magnesium-doped lithium niobate (5% MgO:LN) will be established. Ridge waveguides in MgO:LN will significantly improve the power handling and conversion efficiency, increase photonic component integration, and be well suited to space based applications. The key innovation in this effort is to combine ...

In this Phase I effort our team, a collaboration between Traycer Diagnostic Systems and The University of Notre Dame, proposes to develop a single pixel detector of terahertz frequency electromagnetic radiation. The devices we propose are AlN/GaN high electron mobility transistors which, via the excitation of plasma waves in the device channel, exhibit a nonresonant broadband and resonant respons ...

DESCRIPTION (provided by applicant): The central goal of insulin replacement therapy in the treatment of Type 1 diabetes mellitus (T1DM) is tight control of blood glucose concentration. This Phase I STTR application, submitted by Thermalin Diabetes, Inc., in conjunction with Case Western Reserve University, seeks support for the pre-clinical testing and commercial development of an ultra-stable a ...

DESCRIPTION (provided by applicant): Roughly 500,000 cancer patients are treated with radiotherapy each year. Acute and late sequelae of radiotherapy have a negative impact upon the quality of life of cancer survivors. These sequelae include proctitis, cystitis, esophageal stricture, cutaneous fibrosis plus others. We propose a novel means of preventing the acute and late radiation injury to norma ...

DESCRIPTION (provided by applicant): The long-term goal of this application is to develop mannan derived from Baker's yeast as asthma therapy. The limitations of currently available immunomodulators are their toxicity at higher doses and the lack of beneficial effect on airway smooth muscle (ASM) remodeling and therefore, new adjunctive therapeutics are needed. Initial findings in the P.I.'s labor ...

DESCRIPTION (provided by applicant): Degenerative joint diseases such as osteoarthritis remain the source of significant pain and disability, affecting 20 million adults with an economic burden of over 40 billion per year to the United States. While joint replacement is a well-established procedure, its finite life span makes this treatment unacceptable for younger or more active individuals, of ...

Development of a compliant microfabricated heat exchanger to work with thermoelectric devices as a means of power generation for hypersonic vehicles is proposed. Polymer-based materials provide to provide compression on the thermoelectric module, to ensure optimal thermal contact, while allowing for compliance to allow for the change in materials expansion without exceeding the failure point of th ...

DESCRIPTION (provided by applicant): The American Cancer Society estimates that a total of 240,430 new breast cancers were diagnosed in 2007 (178,400 new cases of invasive breast cancer, and 62,030 new cases of in situ breast cancer). Approximately 180,000 of these patients undergo breast conserving surgery (BCS), also called lumpectomy. Multiple recent studies show that a staggering 20-70% of the ...

In this Phase I STTR program, the project team will develop a mathematical model for the hydrogen permeation inhibiting efficiency for various metals and alloys.  Experiments based on the Devanathan-Stachurski method will be used to determine the models kinetic parameters, which control hydrogen permeation.  The hydrogen entry efficiency and effectiveness of electrodeposited, nanostructured laye ...

This proposal covers investigating and optimizing superconductor cable configuration designs and various cooling methods for lightweight airborne power cables. During this program we will be modeling several types of superconducting cable configurations and design parameters for optimizing the system weight and volume as a function of cable length.  We will study the trade-offs among the influenc ...