Award Data

The Goal of this STTR is to develop a high speed, high power, waveguide based modulator (phase and amplitude) and investigate its use as a pulse slicer. The key innovation in this effort is the use of potassium titanyl phosphate (KTP) waveguides making the high power, polarization based waveguide amplitude modulator possible. Furthermore because it is fabricated in KTP, the waveguide component w ...

This NASA Phase II STTR effort will develop domain-engineered magnesium oxide doped lithium niobate (MgO:LN) for LIDAR-based remote sensing and communication applications. Use of bulk and waveguide-based domain engineered MgO:LN will allow the manufacture of highly efficient and compact, wavelength conversion modules for second-harmonic generation (SHG), sum-frequency generation (SFG), and parame ...

GHe reclamation is critical in reducing operating costs at rocket engine test facilities. Increases in cost and shortages of helium will dramatically impact testing of rocket engines for launch vehicles and space propulsion systems as the global supply of this non-renewable element diminishes. Extremely large quantities of helium are being used during rocket engine testing each year at various t ...

The proposed effort will develop a solid-state LED replacement lamp for rocket engine test stand lighting and more general hazardous-location lighting. The LED lighting will produce a smoother lighting spectrum compared to the existing arc lamp sources which will improve the visual accuracy and quality of high-speed engine photography. The LED lighting will also last significantly longer than ar ...

DESCRIPTION (provided by applicant): Chronic wounds that fail to respond to traditional therapeutic interventions afflict millions of people each year, and direct costs associated with treating these wounds are estimated at 5 to 10 billion annually. Eradication of pathogenic bacteria that have colonized chronic wounds is complicated by the propensity of these bacteria to form ...

DESCRIPTION (provided by applicant): Cystic fibrosis (CF) is the most common life shortening inherited disorder amongst Caucasians, and Pseudomonas aeruginosa pulmonary infections are the leading cause of mortality in CF patients. Treatment of patients infected with P. aeruginosa is complicated by the cell-to-cell signaling systems of this organism, which regulate biofilm formation, virulence gene ...

DESCRIPTION (provided by applicant): By the end of 2006, an estimated 23,000 adults and 15,500 children had received cochlear implants in the United States alone (www.nidcd.nih.gov). The complexity of the system as well as confounding factors such as brainplasticity and changing physiology require that these parameters be continually updated to maximize listening performance and user satisfaction. ...

DESCRIPTION (provided by applicant): The overall goal of our work is to establish the potency and efficacy of a novel 2-adrenergic receptor agonist (compound 49b) in the prevention and/or reversal of non-proliferative diabetic retinopathy. Diabetic retinopathy is the leading cause of blindness in working age adults. The current treatment paradigm for retinopathy patients has not changed signif ...

DESCRIPTION (provided by applicant): The long term goal of this project is to develop and commercialize a drug to treat sleep apnea. Sleep apnea is a common medical condition and associated with excessive daytime sleepiness and is a composite risk for cardiovascular morbidity and mortality. Presently, there are no effective pharmacotherapies for individuals with sleep apnea. Growing evidence from ...

DESCRIPTION (provided by applicant): Congenital diaphragmatic hernia (CDH) affects 1 in 2000 newborns. CDH is a disorder in which part of the diaphragm fails to form, allowing abdominal organs to migrate into the chest, resulting in lung hypoplasia (underdevelopment) in affected infants. Although great strides have been made in the management of this disease, significant morbidity and mortality pe ...