Award Data

The research objectives of this proposal are to: (1) To adapt the thermal-fluid science procedures for the prediction of weld defects to the prediction and control of surface defects and melt pool instability during the deposition of single tracks in SLM and to control the as-deposited microstructure. (2) Utilize physics-based analysis to predict variability caused in the individual SLM track cros ...

GTL has been developing three transformational technologies that have the capability to disrupt the traditional launch vehicle paradigm. BHL composite cryotank technology provides a four times improvement over large Al-Li tanks, offering a 6 percentage point improvement in stage PMF. Superior Stability Engine is an innovative liquid rocket engine configured to maximize combustion stability margi ...

In this Phase II STTR project, RNET and its subcontractors are proposing to fully develop an empirical performance optimization tool called OrFPGA that efficiently explores the "user tunable" parameter space of an FPGA design and assists in deducing the near optimal design in terms of timing score, device utilization, and power consumption. The tunable parameter space will include IPCore parameter ...

The key innovation in this project is the implementation of an Imaging Fourier Transform Spectrometer (IFTS) for in situ metal additive manufacturing process monitoring. In this Phase I STTR project, Mound Laser & Photonics Center, a developer of laser based additive manufacturing processing, will collaborate with the Air Force Institute of Technology, with expertise and innovative hardware for sp ...

DESCRIPTION (provided by applicant): The principle objective of this application is the development of safer and more effective combinatorial therapy for AD. ReXceptor, Inc. is developing new therapeutics for the treatment of AD based on stimulating the physiological clearance mechanisms of soluble forms of A from the brain. Bexarotene is an agonist of the ligand-activated transcription factor, r ...

DESCRIPTION (provided by applicant): Polychromatic flow cytometry [FC] is one of the most powerful analytical techniques routinely used in immunology. Flow cytometry plays a critical role in several growing clinical applications: leukemia and lymphoma immunophenotyping for diagnosis and sub-categorization (now using 8-10 colors); in CD4/CD8 measurement in HIV-positive patients; and in HLA typing f ...

DESCRIPTION (provided by applicant): While minimally invasive surgery has transformed the practice of surgery, access to implants for removal or alteration still requires surgery which generates risk and high cost. A next-generation approach is non-invasive, where implants are adjusted without an incision. There are clear applications in all fields of surgery, but particulary in orthopaedics wher ...

Abstract We propose to initiate preclinical development of a gene therapeutic targeted to Alzheimer's Disease. The World Health Organization's and Alzheimer's Disease International's report on Dementia (2012) recognizes that the global burden of AlzheimerDisease is forecast to worsen significantly with prevalence predicted to double every 20 years. Interventions that could prov ...

DESCRIPTION (provided by applicant): Acute myeloid leukemia (AML) affected ~14,600 new patients in 2013 in the US and caused over 10,000 deaths, primarily in older adults. The current chemotherapy regimen, a combination of cytarabine (AraC) and anthracyclines such as daunorubicin (DNR), has resulted in 5-year survival rates of only 30-40% (less than 10% in patients over 60 years old). The principa ...

? DESCRIPTION (provided by applicant): The goal of this Phase I STTR project is to establish the feasibility of developing a small-molecule therapeutic agent designed to prevent rhabdomyolysis-induced renal failure. Rhabdomyolysis accounts for 7% to 10% of cases of renal failure in the US. Rhabdomyolysis results from muscle injury that leads to the release of myoglobin, which is then deposited ...