Award Data

Future NASA flight missions are considering passive wavefront and amplitude control in astronomical applications such as the search for exo-planets. NASA's Discovery mission proposal called out the need for a coherent 2-dimensional array of fiber bundles for this application. In this SBIR proposal we propose to develop monolithic polarization maintaining (PM) coherent fiber bundle arrays consistin ...

Accurate measurement of atmospheric parameters with high resolution needs advanced lasers. In this SBIR program we propose to develop innovative Q-switched high power 2.05micron fiber laser with pulse energy greater than 10mJ, repetition rate of 10Hz to 1KHz, and pulse duration of 200ns using our proprietary innovative highly efficient Tm-doped glass fiber. This new fiber laser will be an all-fibe ...

The GHz-rate phase-stabilized fiber-laser frequency comb system is proposed to be used as a light source for coherent Fourier transform spectroscopy. The system will be developed based on our proprietary glass/fiber technology, which features a low-cost, robust, highly stable, mid-infrared light source that enables the development of a robust portable c-FTIR spectrometer for absorption measurement ...

DESCRIPTION (provided by applicant): It is estimated that 2 million health-care associated infections are acquired each year by hospitalized patients resulting in 90,000 deaths and about 4.5 billion in excess health care costs. A large and growing percentage of these infections can be attributed to Staphylococcus aureus and, in particular, to methicillin-resistant S. aureus (MRSA). Rapid PCR-base ...

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DESCRIPTION (provided by applicant): Over 700,000 surgical hernia repairs are performed each year in the United States and despite recent advances, a significant rate of recurrence persists. The incorporation of biocompatible mesh to strengthen the abdominal fascia has largely replaced high-tension suturing techniques in hernia repair. Currently, the preferred biomaterials include durable syntheti ...

DESCRIPTION (provided by applicant): Mesenchymal stem cells (MSCs) are an adult stem cell population, typically isolated from bone marrow aspirates, and are capable of self-renewal, expansion in culture, and differentiation into adipocytes, chondrocytes, and osteoblasts. These cells are being explored for use in tissue engineering applications, such as spinal fusions, bone defect repairs, and cart ...

DESCRIPTION (provided by applicant): The emergence of biological therapeutics, including cells, peptides, and proteins, has allowed medical science to address a number of unmet clinical needs. Often these agents are extremely potent, specifically activating endogenous signaling cascades to promote well-characterized biochemical and physiological responses. For example, bone morphogenetic protein-2 ...

DESCRIPTION (provided by applicant): Reaching and engaging Hispanic women, given their central role in families, is a critical strategy in efforts to reduce disparities and improve health outcomes for adults and children in these communities. Quality prenatal care is designed to promote health and reduce risks for women, infants, and families before, during, and after pregnancy. Unfortunately, His ...

DESCRIPTION (provided by applicant): In this Phase II Small Business Innovation Research application, Bioptigen, Inc. proposes to commercialize a deep imaging spectral domain optical coherence tomography (DI-SDOCT) imaging system that incorporates technology proven during the Phase I period to overcome traditional depth limits in OCT and has a maximum, artifact free imaging depth approaching 10 mm ...