Award Data

We believe a robust approach to integrated system health management (ISHM) design is the application of redundancy. Redundancy is often thought of in terms of hardware; however, functional, analytic, and information redundancy strategies should also be considered. Modeling sensor information is invaluable for diagnostics and critical path analysis. A total system approach is an efficient means of ...

The Phase I of the SBIR “Smart Fault Management” project aims to demonstrate how the fault management process can be innovated by exploiting concepts from a combination of well-established and emerging disciplines such as Bayesian Statistics, GPU-accelerated numerical simulations, Data Science, and Machine Learning that are disrupting the current status quo in many scientific and engineering f ...

The proposed research aims to develop a metal matrix composite (MMC) fabric that, when combined with additive manufacturing, will lead to weight reduction, increased structural performance, and reduce fabrication costs of structural components within launch vehicles. The approach focuses on developing a MMC fabric that will be used to selectively reinforce metallic components that are subjected to ...

This project will result in the commercialization of an Intelligent Electronic Speed Controller (IESC) for use on Unmanned Aerial Vehicles (UAVs). The IESC will advance the state-of-the-art of health-state awareness. This will be achieved through the integration of propulsion system health monitoring sensors that - in unison with an Intelligent Rule Set - will be able to monitor system and compone ...

The objective of this proposal is to develop an electronic, rule-based clinical decision support system (CDS-Sx) that leverages national clinical practice guidelines (CPGs) to improve cancer symptom management. Specific tasks that will be performed include: 1) create software-ready computable algorithms for managing cancer-related fatigue and constipation that have been vetted with diverse cancer ...

PROJECT SUMMARYHistone methyltransferasesHMTsare a group of enzymes that represent a critical focal point in the linkage of cellular signals to the regulation of gene expressionThese proteins are not only strongly associated with numerous diseasese gcancersneurodegenerative diseasesand autoimmune disordersbut also have properties that make them excellent targets for drugsThusHMTs provide an except ...

Project SummaryAmong the commercially available systems for single cell isolation and next generation sequencingNGSsample preparationnone are capable of automating both imaging and NGS sample preparation at high throughputWhile single cell genomic analysis has improved in sensitivity and throughputconcomitant improvements in detailed phenotypic characterization of cells has not been integrated int ...

AbstractThe prolific worldwide misuse of organophosphateOPpesticidescoupled with a grave homeland security concern that OP based nerve agents may be deployed either against our troops or civilians on our home soilhas stimulated the search for rapidminiaturized and inexpensive point of carePOCdiagnostic devices for first responders and medical personnel to detect the degree of OP exposureIdentifica ...

The global contraceptives market was valued at $billion inand is expected to grow at a CAGR offromtoto reach an estimated value of $billion inThe contraceptive market consists of short term methods such as condoms and oral contraceptionlong term methods including implants and IUDsand permanent methods such as tubal ligations and vasectomiesEppin Pharmaandapos s product has a unique set of characte ...

Project SummaryOver $billion is spent annually in the US treating chronicnon healing woundsmany of which face lifethreatening complications due to infectionsWound infections are difficult to treat due to the frequency of antibiotic resistance as well as the formation of biofilmsa community of bacteria covered by an extracellular polymeric substanceBiofilm related infections can result in a substan ...