Award Data

DESCRIPTION (provided by applicant): World-wide public health surveys point to an increased global health burden for serious psychiatric disorders, particularly depression. Indeed, by 2020 it is expected that depression may be the second most serious medical condition with respect to global disease burden. It is clear that more effective pharmacotherapies are needed in treating depressive illn ...

In this phase I SBIR program, Advanced Ceramics Research, Inc. (ACR) proposes the development of an innovative, co-curing fabrication process for composite structures with a carbon based aerogel material encapsulated by a polyethylene based composite for radiation shielding applications. The proposed technique will leverage the ACR?s experience with co-injecting highly viscous ceramic slurries int ...

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Advanced Propulsion Inc. proposes a Revolutionary Concept (RevCon) integrated aircraft and propulsion system that provides aircraft drag reduction and propulsion system efficiency increase, thereby improving aircraft fuel efficiency by as much as a factor of two. The key feature is the ducting of a high fraction of the aircraft total boundary layer from distributed airframe inlets to turbofan engi ...

DESCRIPTION (provided by applicant): Phase I. In the treatment of cancer, radiation therapy has been limited by the tolerance of the surrounding normal tissues, such as lung or mucosa. Until now, there have been no compounds available that protect the normal tissues without reducing the tumor response to radiation therapy. The overall goal of this project is to develop a new approach to radiation ...

DESCRIPTION (provided by applicant): The National Institutes of Allergy and Infectious Disease have called for better tools for the detection and diagnosis of emerging and re-emerging infectious diseases. The need is for tests that are practical and affordable for use in resource poor settings, such as local public health departments in underdeveloped countries, disaster situations anywhere, an ...

DESCRIPTION (provided by applicant): The CDC states that lead poisoning is the number one environmental health problem affecting children in the US because it affects one of every six at-risk children and it is acknowledged to be a source of cognitive and behavioral impairment. Only 25% of the at-risk US children are tested. Atomic absorption instruments do 80% of blood lead tests in the US, but t ...

DESCRIPTION (provided by applicant): In this Phase II program we propose continued development of a new nitric oxide (NO) sensor. The sensor is intended for use in assessment of airway inflammation with applications in asthma diagnosis and management as well as in other health care applications involving inflammation in the gastrointestinal tract and the urogenital organs. We use the relatively ne ...

DESCRIPTION (provided by applicant): In this Phase II program we propose continued development of a new nitric oxide (NO) sensor. The sensor is intended for use in assessment of airway inflammation with applications in asthma diagnosis and management as well as in other health care applications involving inflammation in the gastrointestinal tract and the urogenital organs. We use the relatively ne ...

DESCRIPTION (provided by applicant): A hallmark of cancer is deregulated activation of the signal transduction pathways controlling proliferation, apoptosis, and differentiation. The signal transduction pathways culminate in activation of transcription factors (TFs), proteins that bind promoter regions of genes, thereby controlling transcription initiation. To understand the complex regulation ...