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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Delivery of pathogen trapping antibodies for vaginal protection

    SBC: MUCOMMUNE, LLC            Topic: NIAID

    DESCRIPTION provided by applicant Despite immense efforts in behavioral interventions to promote safer sexual practices sexually transmitted infections STIs continue to be a pandemic worldwide Unfortunately there are no effective vaccines or microbicides for the majority of STIs A pathogen specific safe effective and discreet vaginal microbicide that does not require daily or sex associ ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  2. New Class of Bright Sharp Tunable Near Infrared Fluorophores for Flow Cytometry

    SBC: Nirvana Sciences, Inc.            Topic: R

    DESCRIPTION provided by applicant Polychromatic flow cytometry FC is one of the most powerful analytical techniques routinely used by both basic research and clinical diagnostics laboratories for the immunological categorization of cells Dyes used for FC typically exhibit broad fluorescent emission bands with full width at half maximum fwhm values of nm This limits the maximum numbe ...

    STTR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  3. Development and validation of therapy for mucopolysaccharidosis III

    SBC: Phoenix Nest Inc.            Topic: 105

    DESCRIPTION provided by applicant Sanfilippo syndrome mucopolysaccharidosis type III MPS III is a devastating neurodegenerative lysosomal storage disorder of childhood for which there is presently no cure or effective treatment available The fundamental cause of MPS III is an inherited mutation in one of the enzymes required to catabolize heparan sulfate HS a glycosaminoglycan which pla ...

    STTR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  4. Image guided Planning System for Skull Correction in Children with Craniosynostosis Phase II

    SBC: Kitware, Inc.            Topic: NICHD

    DESCRIPTION provided by applicant Craniosynostosis is the premature fusion of cranial sutures and occurs in approximately one in live births It results in cranial malformation that can lead to elevated intra cranial pressure brain growth impairment and developmental deficiency The most common treatment option for craniosynostosis is surgery Currently surgical treatment planning of c ...

    STTR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  5. The CellRaft AIR System Workflow Automation for Stem Cell Isolation and Recovery

    SBC: Cell Microsystems, Inc.            Topic: 200

    DESCRIPTION provided by applicant Stem cell research is an emerging field with the promise of creating dramatic new approaches for disease treatment and drug discovery The research and regenerative medicine market space for stem cells is one of the most dynamic areas in the life science industry today Globally the stem cell market is growing at a CAGR of and will reach an approximate ...

    STTR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  6. Sylvatica I Corps Commercialization Jan High Subzero Equilibrium VCA Cryopreservation

    SBC: Sylvatica Biotech, Inc.            Topic: R

    DESCRIPTION provided by applicant This program targets the long term preservation of vascularized composite tissues for both autologous and allotransplantation VCA such as of e g muscle flaps digits faces and whole limbs to radically improve restorative and reconstructive medicine We have conceived an integrated two pronged approach in which we will develop new nature inspired and furt ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  7. A Novel TLR Agonist Based Adjuvant for Poliovirus Vaccine

    SBC: BUFFALO BIOLABS, LLC            Topic: NIAID

    PROJECT SUMMARY ABSTRACT Antiviral vaccines remain the largest segment of the rapidly growing global vaccine market Despite near complete eradication of poliovirus through vaccination efforts continued need for inactivated polio vaccine IPV is projected to reach million doses per year worldwide Among major obstacles to widespread use of the current IPV formulation are its high cost and in ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  8. Off-the-Shelf Patch for Repairing Tracheal Stenosis

    SBC: Nanofiber Solutions, Inc.            Topic: NHLBI

    DESCRIPTION provided by applicant The long term objective of this application is to bring a trachea patch to the market to treat tracheal stenosis or narrowing of the airway which left untreated is a life threatening condition that affects both young children and adults Currently otolaryngologists have only two major options for treating tracheal stenosis One is a complex surgical procedu ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  9. rhMFG E as an Effective Adjuvant Therapy for Hemorrhagic Shock

    SBC: THERASOURCE, LLC            Topic: NHLBI

    DESCRIPTION provided by applicant The primary objective of this project is to further demonstrate the feasibility of developing recombinant human milk fat globule epidermal growth factor factor rhMFG E as a novel and effective adjuvant therapy for the resuscitation of patients with hemorrhagic shock Hemorrhagic shock is a major cause of mortality worldwide In the United States traumatic ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  10. Tau Oligomer Platform Validation Using Lead Series Candidate in htau Mice

    SBC: Oligomerix, Inc.            Topic: NIA

    DESCRIPTION provided by applicant The prevalence of Alzheimerandapos s disease AD is increasing worldwide due to demographic shifts resulting from an aging population It is the most costly disease in the US with a financial burden of over $ billion annually in direct costs that are estimated to increase to $ trillion by Disease modifying drugs that change the clinical course and de ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health

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