Award Data

DESCRIPTION (provided by applicant): Autoimmune diseases are thought to arise from abnormalities in innate or adaptive immune responses and most likely have both genetic and environmental components. Diagnosis of autoimmune disease is often difficult, as t he symptoms can be relatively nonspecific. Furthermore, no available blood test can accurately exclude the possibility of an autoimmune disease ...

DESCRIPTION (provided by applicant): Web-Based Wellness Policy Toolkit for Obesity Prevention in Middle Schools The childhood obesity epidemic is escalating with significant adverse health and economic impact. We propose to develop and test a web-based too lkit designed to facilitate implementation of required wellness policies (WP) in middle schools as well as a commercialization strategy for und ...

Existing and planned neutron facilities, such as the Spallation Neutron Source, generate bursts of cold neutrons for materials research. The efficiency of the beam line components, which convert the fast neutrons to a cold neutron beam, determines the usefulness of the facility. Existing solid methane moderators have a high efficiency, but cannot be scaled to work on high power facilities. A co ...

Many Scientific and technical data sets have been placed in a distributed set of data repositories, and more are added continuously. Internet search engines can provide some answers to user queries, but the quality and completeness of the results are uneven and unreliable. This project will demonstrate how an integrated tool can locate, harvest, and deposit data into a user-specified repository. ...

DESCRIPTION (provided by applicant): A New Modular Tool Set for Live Imaging and Manipulating the Nervous System Project summary. The nervous system contains the most complex and heterogeneous set of cell types in the body. Modern approaches in imaging, an d genetically encoded reporters based on the Green Fluorescent Protein (GFP), have made it possible to explore some of the dynamic processes in ...

DESCRIPTION (provided by applicant): This Small Business Technology Transfer (STTR) proposal responds to program announcement PAS-06-131 entitled, Applications of Imaging and Sensor Technologies for Clinical Aging Research . The purpose of the announcemen t is to improve imaging methods for measuring age-related changes in regulation of complex physiologic systems, including responses to stimuli ...

The Department of Energy¿s large research facilities need improved neutron detectors for thermal neutron instrumentation. Where large detector arrays are needed, single-wire overpressured 3He tube detectors are the detector of choice, because they are so cost effective. Though useful, current detectors do not meet the demands of current high intensity neutron sources, such as the Spallation N ...

DESCRIPTION (provided by applicant): PharmacoPhotonics, LLC proposes research leading to a novel 2-photon in vivo fluorescence method for monitoring glomerular filtration rate (GFR) in acute kidney injury (AKI). AKI remains a vexing clinical problem result ing in unacceptably high patient mortality, development of chronic kidney disease and enhanced progression to end stage renal disease. Although ...

DESCRIPTION (provided by applicant): A significant problem currently hindering proteomics studies is the identification of peptides and proteins from mass spectral data. This problem is manifest in the difficulty to establish confidence limits of protein a nd peptide identifications. A serious concern is the tendency for the occurrence of false positive assignments. The development of an integrate ...

Geologic carbon sequestration has the potential to store a century¿s worth of anthropogenic carbon dioxide production. However, this solution will require numerous large underground reservoirs that may extend over hundreds of square kilometers and an extensive network of pipelines, some of which will be on the order of hundreds of kilometers long. Consequently, very large areas will need to b ...