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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Development of Lysosomal Modulatory Drugs to Treat Alzheimer's Disease

    SBC: SYNAPTIC DYNAMICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Reducing protein deposition events is essential for slowing the progression of Alzheimer's disease (AD), especially A 1-42 peptide oligomers that accumulate inside and outside neurons and cause functional compromise. Finding a strategy to reduce A oligomeric assemblies is widely thought to be the key objective for treating AD. Accumulation of A peptides is on ...

    STTR Phase I 2009 Department of Health and Human ServicesNational Institutes of Health
  2. Visualization Technologies for Distribution Systems

    SBC: Signatech Systems            Topic: 62a

    Vast amounts of data are available to quantify the supply and demand of electricity in a distributed system. However, distribution operators require a more succinct depiction of the data through effective visualization. Therefore, this project will develop, test, and conduct user experiments to determine the impact of interactive visualization tools on a specific distribution system model, such a ...

    STTR Phase I 2009 Department of Energy
  3. Development and Neutronic Validation of Pelletized Cold and Very Cold Moderators for Pulsed Neutron Sources

    SBC: Cryogenic Applications F, Inc.            Topic: 01a

    Existing and planned neutron facilities, such as the Spallation Neutron source, generate bursts of cold neutrons for materials research. The efficiency of the beam line components, which convert the fast neutrons to a cold neutron beam, determines the usefulness of the facility. Existing solid methane moderators have a high efficiency, but can¿t be scaled to work on high power facilities. A cold ...

    STTR Phase II 2009 Department of Energy
  4. Radioprotection by use of Topical Lithium Formulations

    SBC: CUMBERLAND PHARMACEUTICALS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Roughly 500,000 cancer patients are treated with radiotherapy each year. Acute and late sequelae of radiotherapy have a negative impact upon the quality of life of cancer survivors. These sequelae include proctitis, cystitis, esophageal stricture, cutaneous fibrosis plus others. We propose a novel means of preventing the acute and late radiation injury to norma ...

    STTR Phase I 2009 Department of Health and Human ServicesNational Institutes of Health
  5. Mannan, A Potential Therapeutic for Asthma

    SBC: CUMBERLAND PHARMACEUTICALS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The long-term goal of this application is to develop mannan derived from Baker's yeast as asthma therapy. The limitations of currently available immunomodulators are their toxicity at higher doses and the lack of beneficial effect on airway smooth muscle (ASM) remodeling and therefore, new adjunctive therapeutics are needed. Initial findings in the P.I.'s labor ...

    STTR Phase I 2009 Department of Health and Human ServicesNational Institutes of Health
  6. Functional Tissue Engineering for Cartilage Repair

    SBC: Cytex Therapeutics, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Degenerative joint diseases such as osteoarthritis remain the source of significant pain and disability, affecting 20 million adults with an economic burden of over 40 billion per year to the United States. While joint replacement is a well-established procedure, its finite life span makes this treatment unacceptable for younger or more active individuals, of ...

    STTR Phase I 2009 Department of Health and Human ServicesNational Institutes of Health
  7. Fast Spectral Imaging Device For Tumor Margin Mapping

    SBC: Zenalux Biomedical, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): The American Cancer Society estimates that a total of 240,430 new breast cancers were diagnosed in 2007 (178,400 new cases of invasive breast cancer, and 62,030 new cases of in situ breast cancer). Approximately 180,000 of these patients undergo breast conserving surgery (BCS), also called lumpectomy. Multiple recent studies show that a staggering 20-70% of the ...

    STTR Phase II 2009 Department of Health and Human ServicesNational Institutes of Health
  8. Development of ADAM10 Prodomain as a Therapeutic Agent

    SBC: BIOZYME, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Recent cancer therapies have focused on using biologics to target specific signal transduction pathways implicated in the tumor development or progression. For example, recombinant fusion proteins consisting of the extracellular domain of the immunoregluatory proteins and the constant (Fc) domain of immunoglobulin (IgG) represent a growing class of protein ther ...

    STTR Phase I 2009 Department of Health and Human ServicesNational Institutes of Health
  9. A Universal Brain Atlas for Implanting and Managing Deep Brain Stimulators

    SBC: Neurotargeting, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Neurotargeting, LLC proposes to develop the technical support infrastructure as well as clinical tools for a commercial software product that will provide a global service for the medical community involved in deep brain stimulator (DBS) therapy. Specifically, this Phase I study will explore the use of a physiological atlas database that can interface with a nu ...

    STTR Phase I 2009 Department of Health and Human ServicesNational Institutes of Health
  10. New Serodiagnostics for Isocyanate Exposure, A Major Cause of Occupational Asthma

    SBC: L2 DIAGNOSTICS LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Through a Phase I STTR grant, we developed a blood-based enzyme-linked immunosorbant assay (ELISA) to fulfill an important unmet need in public health efforts against occupational asthma. The ELISA quantitates antibodies that specifically recognize and bind to the self-protein, albumin, which has been modified by chemical reactivity with isocyanate, the most co ...

    STTR Phase II 2009 Department of Health and Human ServicesNational Institutes of Health
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