Award Data

Advanced Computation and Engineering Services proposes to develop new and innovative modeling concepts to more accurately define and predict the failure modes of various fabric materials from current and futuristic ballistic impacts, working closely with North Carolina State University and conferring with engineers at body armor manufactures. Extensive research has been conducted by various gover ...

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DESCRIPTION (provided by applicant): Rapid and accurate detection and identification of pathogens is crucial for the effective management and treatment of infectious disease. While molecular diagnostic techniques including PCR are a promising approach for rapid and sensitive detection of pathogens, they suffer from a number of technical drawbacks which have slowed their acceptance in the clinic. ...

Conventional docking tests take a long time because of the many degrees of freedom. Additionally, large libraries of small molecules are tested without adequately using feedback about their suitability as inhibitors from previous tests. We propose a rapid initial screen that can computationally evaluate large numbers of small molecules so that a subset may be selected for further computational ana ...

DESCRIPTION (provided by applicant): In this proposal, we present a novel approach for the identification and immobilization of a BMP mimetic. We plan to use phage display technology to identify peptides that mimic BMP-like signaling of the BMP receptors. These peptides will be linked to a previously identified high-affinity, collagen-binding peptide. The resulting hybrid molecule will allow contr ...

Endosseous metallic implants are common alloplastic devices used in medicine and dentistry. The orthopedic and dental marketplace continues to grow and indications for implants are expanding. There is a perceived need to improve both the successful healing (osseointegration) and the long term outcome of implants by control of interfacial reactivity during healing and remodeling. The growth of know ...

DESCRIPTION (provided by applicant): In this Phase I SBIR project Alderon Biosciences Inc. (ABI) proposes to demonstrate the feasibility of using electrochemical reverse transcriptase (eRT) assays for determinations of HIV viral load in clinical samples. Success will set the stage for Phase II development, FDA approval, and production of commercial kits using this advanced technology. The long-r ...

DESCRIPTION (provided by applicant): The National Institutes of Allergy and Infectious Disease have called for better tools for the detection and diagnosis of emerging and re-emerging infectious diseases. To meet this need, Alderon Biosciences Inc. (ABI) proposes to develop innovative, low-cost tests with sensitivity adequate for determining HCV viral load. Reliable and affordable HCV viral load t ...

Innovative damping methods for small turbine engines are needed by the Army and other military and commercial interests. The plasma sprayed coating process provides a method for successfully achieving the required damping for the newer high efficiency turbine engines that experience high "g " loads between 800 °F and 2000 °F. Plasma sprayed ceramic coatings have demonstrated significant damping ...

DESCRIPTION (provided by applicant): Cardiovascular disease is the leading cause of morbidity and mortality in the United States, accounting for approximately 1 million deaths per year. The objective of the Phase I pre-clinical studies outlined in this fasttrack STTR proposal is to validate the proposed methods of isolation, characterization, and administration of preferred progenitor cell prepar ...