Award Data

DESCRIPTION (provided by applicant): The human genome contains at least 30,000 unique open reading frames that may yield >100,000 polypeptide products. These products assemble into more than a million biologically relevant structures or proteins of interest per organism. Crystallization and X-ray diffraction of these proteins is routinely performed to determine their 3D structure which needs to be ...

DESCRIPTION (provided by applicant): Latrogenic blood loss or "bleeding into the laboratory" is an important reason for administration of small volume transfusions in very low birth weight premature 6infants. A direct correlation was found between the volume of blood drawn for diagnostics and subsequent volume transfused. In neonatal infants, there may not be enough collected blood sample to perfo ...

DESCRIPTION (provided by applicant): The development of clinically effective cancer vaccines requires reliable analytical methods to evaluate the immune response to vaccination. Immunoassays are among the most sensitive and specific analytical methods that have been used widely in cancer vaccine research, most commonly to monitor the release of cytokines from T-cells in response to vaccination. A ...

During Phase I, 3TEX designed universal, one-piece, 3D woven fiber preforms which can be used as either a “Butt” (H) joint or as a “P” joint as needed. Composite joints were fabricated and tested, demonstrating the benefit of the integral nature of the 3D preforms. 3D stress/strain and crack propagation analysis of composite Π-joint was performed using 3D MOSAIC code. 3D displacement, st ...

Military helicopters rotors contend with rain, ice, sand, and flying debris. To prevent damage to the expensive blade protective sheaths or coatings are applied to the leading edge of the rotor blades. A 3-D woven composite sheath with high thermal conductivity fibers running through the thickness can offer the best qualities of both metal sheaths and elastomer coatings. Infused with an elastom ...

Miller Fasteners made from 2-D laminates represent the state of the art in joining CMC panels to metal frames. Despite its success, the extant Miller fastener design is limited by its construction from a laminate of 2-D fabric. The resultant fastener part has poor interlaminar shear strength, and its manufacture and application entails high machining costs and high material scrap rates. 3TEX, i ...

DESCRIPTION (provided by applicant): Summary/Abstract Diabetic foot ulcers are a significant health problem that imposes high costs on both patients and society (Boulton, Vileikyte et al. 2005). A large proportion of foot ulcers remain unresponsive to available conventional treatment and their associated complications and costs have prompted extensive research that has led to promising breakthroug ...

DESCRIPTION (provided by applicant): There are over 6.3 million fractures each year in the United States of which approximately 700,000 are difficult to heal. The available treatment options for fractures that do not heal or are slow to heal are limited. Bone morphogenetic proteins are growth factors that stimulate new bone production and have received FDA approval for bone fracture repair and spi ...

DESCRIPTION (provided by applicant): Many contemporary medical and dental therapies include the replacement or repair of tissues using materials such as metal. Currently there are at least 150,000 hip replacements, 300,000 knee replacements, and 500,000 dental implant procedures performed in the US each year (Kurtz, Mowat et al. 2005). These numbers are expected to increase as the baby boom gen ...

DESCRIPTION (provided by applicant): Two recombinant human Bone Morphogenetic Proteins (BMP's), rhBMP-2 and rhBMP-7, are currently used in clinical applications to promote spinal fusion and fracture healing (Mont, Ragland et al. 2004). Over 6.3 million fractures occur each year in the United States alone (Praemer, Furner et al. 1999). Approximately 15% of fractures have delayed or impaired healing ...