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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. PLATFORM FOR NEUROCOGNITIVE EVALUATION AND MONITORING

    SBC: ENFORMIA INC.            Topic: NCI

    Current standardized neuropsychological tests are based on decades old paper and pencil methods They lack reliability sensitivity specificity repeatability and require trained neuropsychologists to administer them Their administration in clinical and research settings result in high cost complexity and inconsistent results There is a need and a commercial opportunity for an extensible co ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. A user friendly point of care device for G PDH determination

    SBC: ANALYTICAL DIAGNOSTIC SOLUTIONS INC            Topic: NIAID

    Malaria caused by Plasmodium vivax threatens over billion people globally and sickens tens of millions annually Radical cure for P vivax malaria includes therapy aimed both at the acute attack blood schizontocidal and against future attacks hypnozoitocidal The only hypnozoitocide available are aminoquinolines such as primaquine or tafenoquine However clinicians often do not prescribe ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. An RNA targeted platform for anti flavivirus drug discovery

    SBC: Ribometrix LLC            Topic: NIAID

    SUMMARY Emerging and re emerging mosquito borne flaviviruses cause widespread mortality morbidity and economic burden Options for prevention and treatment of mosquito borne flaviviruses are limited Flavivirus vaccines face unique development challenges no antiviral therapies are available and the mosquito vectors have proven difficult to eradicate Despite vaccines against Yellow Fever and J ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Interstitial Intensity Modulated Photodynamic Therapy i IMPDT

    SBC: SIMPHOTEK, INC.            Topic: 102

    Over worldwide cases of head and neck Handamp N cancer occur annually Despite aggressive treatment about of Handamp N cancers recur and progress Recent studies of interstitial PDT I PDT have shown promising results in the treatment of patients with locally advanced Handamp N cancer that fail standard therapies I PDT provides a means to treat cancerous tumors while minimizing da ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Peptide based tool for the rapid isolation of quiescent monocytes from peripheral blood

    SBC: AFFINERGY, LLC            Topic: 102

    SUMMARY ABSTRACT Dendritic cell DC therapy represents a new and promising immunotherapeutic approach for treatment of advanced stage cancers with DC vaccines already approved for use in advanced prostate cancer and more than DC based vaccines in the clinical development pipeline for other cancers In particular the US market for cancer vaccines including DC based vaccines is set to expan ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Improved cleaning technology for reducing risk of transmitting infection in endoscopy

    SBC: ADVANCED BIODEVICES LLC            Topic: NIAID

    Project Summary Abstract More than million procedures were performed with GI endoscopic devices in Since endoscopes cannot be sterilized risk of infection from contaminated endoscopes can be tangible and needs to be urgently addressed Infection at endoscopy has recently been recognized as a significant risk after two patient deaths from CRE infection transmitted by contaminated duodenos ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Novel enzyme inhibitor screening platform using modified designer nucleosomes

    SBC: Epicypher, Inc.            Topic: 300

    Project Summary Nucleosomes are the basic units of chromatin comprised of a histone octamer made up of two copies of each of the histone subunits H A H B H and H Changes in chromatin structure and function are mediated through histone post translational modifications PTMs such as methylation and ubiquitination Alterations of specific PTMs are highly associated with human diseases i ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Microfluidic S nitrosothiol Sensor

    SBC: CLINICAL SENSORS, INC.            Topic: 400

    PROJECT SUMMARY This Small Business Innovation Research SBIR Phase I project aims to develop an accurate rapid and commercially available microfluidic sensor that measures low molecular weight S nitrosothiols in biological samples S nitrosothiols RSNOs the primary transporters of nitric oxide NO in physiology play a critical role for NOandapos s bioactivity Homeostatic control of low ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. High throughput screening of arrayed single cells for automated analysis of phenotypic heterogeneity

    SBC: Celldom, Inc.            Topic: 300

    ABSTRACT The overall objective of this SBIR Phase I proposal is to develop a high throughput screening platform that can analyze the phenotypic heterogeneity of single cells exposed to small molecule growth inhibitors To achieve this objective we will conduct the following specific aims demonstrate a commercially viable approach for rapidly organizing andgt single cells into an arra ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Centralized assay datasets for modelling support of small drug discovery organizations

    SBC: COLLABORATIONS PHARMACEUTICALS INC            Topic: 400

    Summary The objective of Assay Central is to compile a comprehensive collection of datasets for structure activity data for a broad variety of disease targets and absorption distribution metabolism excretion and toxicology ADMET properties in a form that is immediately ready for model building and other forms of analysis using cheminformatics methods This is aided by the existence of many ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
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