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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Satellite Ground Station Network for Real-Time Space Weather Data

    SBC: USML L.L.C.            Topic: 843W

    The goal of this Phase II effort is to carry out a series of tasks with the purpose of developing a ground station network that can provide less than 15 minute latency in acquiring data from NOAA space weather assets. These tasks include:  Finalize a set of specifications for ground stations so they can be used to determine the suitability of existing ground stations for the different missions ...

    SBIR Phase II 2017 Department of Commerce
  2. PLATFORM FOR NEUROCOGNITIVE EVALUATION AND MONITORING

    SBC: ENFORMIA INC.            Topic: NCI

    Current standardized neuropsychological tests are based on decades old paper and pencil methods They lack reliability sensitivity specificity repeatability and require trained neuropsychologists to administer them Their administration in clinical and research settings result in high cost complexity and inconsistent results There is a need and a commercial opportunity for an extensible co ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. An RNA targeted platform for anti flavivirus drug discovery

    SBC: Ribometrix LLC            Topic: NIAID

    SUMMARY Emerging and re emerging mosquito borne flaviviruses cause widespread mortality morbidity and economic burden Options for prevention and treatment of mosquito borne flaviviruses are limited Flavivirus vaccines face unique development challenges no antiviral therapies are available and the mosquito vectors have proven difficult to eradicate Despite vaccines against Yellow Fever and J ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Supporting Healthy Aging with a Phytochemical Combination that Acts at Multiple Control Points in the Nrf Activation Pathway

    SBC: Pathways Bioscience, LLC            Topic: NIA

    The average lifespan and the number of older individuals is increasing in the US but because age is a primary risk factor for most chronic disease there is an accompanying increase in the burden of chronic disease in the US Diet and lifestyle choices including dietary supplementation may be useful approaches to slowing the aging process and increasing healthspan and also may be the best stra ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. "Modulation of Immune Checkpoints by Self Deliverable RNAi for Adoptive Cell Transfer"

    SBC: ADVANCED RNA TECHNOLOGIES LLC            Topic: 102

    Two of the most promising approaches to cancer immunotherapy are immune checkpoint blockade by monoclonal antibodies and the adoptive transfer of immune cells The recent successes in treating melanoma with anti PD and anti CTLA antibodies as well as the extremely successful application of T cells engineered to express the CAR receptor targeting CD to treat B cell lymphomas initiated a waterfal ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Peptide based tool for the rapid isolation of quiescent monocytes from peripheral blood

    SBC: AFFINERGY, LLC            Topic: 102

    SUMMARY ABSTRACT Dendritic cell DC therapy represents a new and promising immunotherapeutic approach for treatment of advanced stage cancers with DC vaccines already approved for use in advanced prostate cancer and more than DC based vaccines in the clinical development pipeline for other cancers In particular the US market for cancer vaccines including DC based vaccines is set to expan ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. High sensitive and specific Point of use lateral flow strip for on site test of cannabis intoxication

    SBC: Vitan-Biotech LLC            Topic: NIDA

    Project Summary Marijuana e g cannabis is the most frequently detected drug of abuse Cannabis abuse has a substantial impact on public safety as driving under the influence of cannabis will impair driving skill and the marijuana use in the workplace will increase the risk of adverse events and the loss of productivity With the recent wave of legalization of marijuana use in numerous states ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Novel enzyme inhibitor screening platform using modified designer nucleosomes

    SBC: EPICYPHER, INC.            Topic: 300

    Project Summary Nucleosomes are the basic units of chromatin comprised of a histone octamer made up of two copies of each of the histone subunits H A H B H and H Changes in chromatin structure and function are mediated through histone post translational modifications PTMs such as methylation and ubiquitination Alterations of specific PTMs are highly associated with human diseases i ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Microfluidic S nitrosothiol Sensor

    SBC: CLINICAL SENSORS, INC.            Topic: 400

    PROJECT SUMMARY This Small Business Innovation Research SBIR Phase I project aims to develop an accurate rapid and commercially available microfluidic sensor that measures low molecular weight S nitrosothiols in biological samples S nitrosothiols RSNOs the primary transporters of nitric oxide NO in physiology play a critical role for NOandapos s bioactivity Homeostatic control of low ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. High throughput screening of arrayed single cells for automated analysis of phenotypic heterogeneity

    SBC: Celldom, Inc.            Topic: 300

    ABSTRACT The overall objective of this SBIR Phase I proposal is to develop a high throughput screening platform that can analyze the phenotypic heterogeneity of single cells exposed to small molecule growth inhibitors To achieve this objective we will conduct the following specific aims demonstrate a commercially viable approach for rapidly organizing andgt single cells into an arra ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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