Award Data

Currently, there are over 10,000 MRI scanners used in the US alone. US citizens today are mobile and many times medical treatments may require MRI scans from several different facilities. Images from MRI scanners can also drift over time. There is a tremendous need for all medical imaging scanners to be on the same level. Sigma-K will develop the commercialization of the ISMRM/NIST MRI Calibration ...

DESCRIPTION (provided by applicant): Staphylococcus aureus is the second leading cause of hospital-acquired bloodstream infections. In 2003, nearly 300,000 patients in US hospitals acquired an S. aureus infection, which accounted for nearly three million days of hospitalization, 9.5 billion in excess costs, and at least 12,000 inpatient deaths. Additionally, approximately 50% of the US population ...

DESCRIPTION (provided by applicant): Skeletal muscle wasting is a serious condition prevalent in the aging population (sarcopenia) and in a variety of specific diseases. This condition results in loss of muscle function through impaired muscle regeneration, resulting in an increase in falls and injuries, a loss of independence, and a reduced quality of life. These changes produce a large health ca ...

DESCRIPTION (provided by applicant): Heparin and its derivatives block P- and L-selectin mediated metastatic spread of cancer in animal models, and they potently inhibit the matrix degrading enzyme heparanase. Moreover, several large clinical trials performed with heparin or low molecular weight heparin have shown that survival is significantly improved by daily subcutaneous administration of hepa ...

DESCRIPTION (provided by applicant): This Phase I application requests funds to support the continued preclinical evaluation of a novel opioid analgesic, PPL-103, and the synthesis and initial preclinical evaluation of a series of new analogs thereof.PPL-103, a potent analgesic, has undergone early preclinical studies by Phoenix PharmaLabs, Inc. (PPL), the applicant organization, and NIDA. PPL ...

DESCRIPTION (provided by applicant): Bone cements are widely used in maxillofacial surgery, repair of cranial defects, and dental fillings. Calcium phosphate bone cements are useful in many types of bone repair because they conform to the defect area, harden in situ, and can be resorbed and replaced by new bone. When the cements are injectable, they can also be used for minimally invasive surgery ...

DESCRIPTION (provided by applicant): Chronic gingival inflammation afflicts over half of all American adults and can progress to periodontal disease, eventually resulting in tooth loss. Periodontitis is initiated by bacterial infection of the gingival tissues through a subgingival microbial biofilm on the tooth surface that releases bacterial lipopolysaccharide (LPS) and other antigens. In turn, L ...

DESCRIPTION (provided by applicant): The purpose of this project is to research and develop digital media-based nutrition education materials for low science literacy, underserved, and minority patients receiving dialysis treatment for ESRD. The developedmaterials will lay the foundation and serve as prototypes for a Phase II NIH SBIR application aimed at full development and marketing of an inter ...

DESCRIPTION (provided by applicant): Though the USPSTF recommends all clinicians intervene with obese adults (AHRQ, 2003), less than half of patients are assessed, counseled, or otherwise treated for obesity. This project will create an innovative web-based continuing professional development program for primary care providers (PCPs) available at: //www.ImpactObesity.com to improve PCP care of obe ...

DESCRIPTION (provided by applicant): Approximately 24 million adults and children in the United States have 1 Diabetes Mellitus (diabetes) and 1.6 million new cases are diagnosed each year. Type 2 is the most common form of the disease accounting for over90% of the diabetics worldwide. The remaining 5 to 10% of diabetics are plagued with the more serious Type 1 condition which is most often diagno ...