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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Continuous Monitoring of Natural Gas Infrastructure for Increased Community Resilience using Voltammetric Sensors

    SBC: FULLMOON SENSORS, INC.            Topic: None

    Fullmoon has the first chip-level sensors capable of identifying and quantifying molecules in the air. At the core of our technology are printed voltammetric sensors, which are operated using cyclic voltammetry, an electrochemical technique that probes for the redox potential, a unique signature of molecules. We have demonstrated this sensing principle for the detection of carbon monoxide and meth ...

    SBIR Phase I 2019 Department of CommerceNational Institute of Standards and Technology
  2. Microcapillary Quartz Sensors for Screening Injectability of High Concentration Protein Formulations

    SBC: Qatch Technologies, LLC            Topic: None

    The objective of this SBIR Phase I proposal is to determine the feasibility of viscosity characterization of high concentration protein formulations (HCF) by QATCH’s microcapillary quartz technology. HCFs are non-Newtonian fluids with shear-thinning behavior and they are administered to patients by subcutaneous or muscular injections. The injectability of HCFs depends on the viscosity at high-sh ...

    SBIR Phase I 2019 Department of CommerceNational Institute of Standards and Technology
  3. Compact Raman Fiber Optic Probe with Inline Spectral Filtering

    SBC: Nikira Labs Inc.            Topic: None

    In this Small Business Innovative Research (SBIR) effort, Nikira Labs Inc. proposes to develop a compact Raman fiber optic probe with inline spectral filtering that improves fiber-coupled Raman measurements by filtering out Raman scattering from the excitation fiber and elastically scattered laser light from the collection fibers. The technology will enable compact fiber probes for Raman studies i ...

    SBIR Phase II 2019 Department of CommerceNational Institute of Standards and Technology
  4. Developing Silicon Nanowire Sensors to Measuring Host-Cell Proteins at a Biomanufacturing Line

    SBC: Advanced Silicon Group            Topic: None

    Our biosensor is made of silicon nanowire arrays functionalized with antibodies to measure the concentration of specific proteins. In this grant we will take a sensor that has been demonstrated for use in measuring a set of generic host cell proteins and we will apply the sensor to measure a set of proteins for a specific cell line. In doing so, we will demonstrate the utility of our sensor to be ...

    SBIR Phase II 2019 Department of CommerceNational Institute of Standards and Technology
  5. Extended Release of Pyridostigmine Bromide for Effectively Combating Nerve Agent Exposure

    SBC: Innosense Llc            Topic: CBD181004

    Chemical warfare agents such as the lethal nerve agent soman are a major source of risk to military personnel. Currently, pyridostigminebromide (PB) is the only FDA-approved pretreatment to counteract the effects of soman. The rationale behind PB administration is that it actsas a temporary inhibitor of AChE. This precludes nerve agents from irreversible inactivation of AChE, thereby mitigating th ...

    SBIR Phase I 2019 Department of DefenseOffice for Chemical and Biological Defense
  6. Biphase Extended Release Tablet Formulation for Nerve Agent Pretreatment

    SBC: Zymeron Corporation            Topic: CBD181004

    Given the unforeseen/unanticipated use of nerve agents in the battlefield and on the homeland, military personnel can benefit from this oncedaily pretreatment. It may also be desirable to pretreat certain medical and emergency aid personnel following a known/suspected nerveagent attack. Also, a novel, improved PB extended release formulations can be commercialized for the treatment of myasthenia g ...

    SBIR Phase I 2019 Department of DefenseOffice for Chemical and Biological Defense
  7. Dual Formulation of Atropine and Scopolamine with Enhanced Stability

    SBC: Nano Terra, Inc.            Topic: CBD181005

    The standard US military treatment for nerve agent exposure is application of up to three autoinjectors, each containing atropine sulfate and2-pralidoxime, to counteract symptoms of nerve agent intoxication and restore acetylcholinesterase activity. This treatment increases survivalrates after nerve agent exposure, however, seizures resulting from nerve agent poisoning are a common symptom that ca ...

    SBIR Phase I 2019 Department of DefenseOffice for Chemical and Biological Defense
  8. Durable Stretch Barrier Materials

    SBC: LaunchBay LLC            Topic: CBD181003

    Chemical, Biological, Radioactive and Nuclear (CBRN) protective ensembles are widely used by the US Military and civilian first responders asthe first line of defense for personnel working in contaminated environments. Many innovative products have been developed for thechemical protective clothing market in response to demand from the market place for improved performance. However, the need forte ...

    SBIR Phase I 2019 Department of DefenseOffice for Chemical and Biological Defense
  9. Photoacoustic Gasses Optical Detector and AnalyzerPhotoacoustic Gasses Optical Detector and Analyzer

    SBC: PHYSICAL OPTICS CORPORATION            Topic: CBD171004

    To address the CBDs need for real-time analytical technology for multicomponent vapor identification and quantification, Physical OpticsCorporation (POC) proposes to continue the development of a new Photoacoustic Gasses Optical Detector and Analyzer (PAGODA)autonomous, network-enabled photoacoustic spectrometer (PAS) for the correlation, analysis, and identification of measured spectra. In thePha ...

    SBIR Phase II 2019 Department of DefenseOffice for Chemical and Biological Defense
  10. Open-Path Spatial Ring Down Spectrometer for Chemical Vapor Detection

    SBC: Physical Sciences Inc.            Topic: CBD171004

    Physical Science Inc. (PSI) will develop a new approach to chemical vapor detection based on a novel open-path sample cell design. The PhaseI system level model predicts SNR supporting a probability of detection of 95% and a MTBFA of 168 hours for all relevant CWAs and TICs at the10 minute negligible MEG level at a 20 s measurement time. In addition to robust detection, the system design can provi ...

    SBIR Phase II 2019 Department of DefenseOffice for Chemical and Biological Defense

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