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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Microcapillary Quartz Sensors for Screening Injectability of High Concentration Protein Formulations

    SBC: Qatch Technologies, LLC            Topic: None

    The objective of this SBIR Phase I proposal is to determine the feasibility of viscosity characterization of high concentration protein formulations (HCF) by QATCH’s microcapillary quartz technology. HCFs are non-Newtonian fluids with shear-thinning behavior and they are administered to patients by subcutaneous or muscular injections. The injectability of HCFs depends on the viscosity at high-sh ...

    SBIR Phase I 2019 Department of CommerceNational Institute of Standards and Technology
  2. Developing Silicon Nanowire Sensors to Measuring Host-Cell Proteins at a Biomanufacturing Line

    SBC: Advanced Silicon Group            Topic: None

    Our biosensor is made of silicon nanowire arrays functionalized with antibodies to measure the concentration of specific proteins. In this grant we will take a sensor that has been demonstrated for use in measuring a set of generic host cell proteins and we will apply the sensor to measure a set of proteins for a specific cell line. In doing so, we will demonstrate the utility of our sensor to be ...

    SBIR Phase II 2019 Department of CommerceNational Institute of Standards and Technology
  3. Biphase Extended Release Tablet Formulation for Nerve Agent Pretreatment

    SBC: Zymeron Corporation            Topic: CBD181004

    Given the unforeseen/unanticipated use of nerve agents in the battlefield and on the homeland, military personnel can benefit from this oncedaily pretreatment. It may also be desirable to pretreat certain medical and emergency aid personnel following a known/suspected nerveagent attack. Also, a novel, improved PB extended release formulations can be commercialized for the treatment of myasthenia g ...

    SBIR Phase I 2019 Department of DefenseOffice for Chemical and Biological Defense
  4. Dual Formulation of Atropine and Scopolamine with Enhanced Stability

    SBC: Nano Terra, Inc.            Topic: CBD181005

    The standard US military treatment for nerve agent exposure is application of up to three autoinjectors, each containing atropine sulfate and2-pralidoxime, to counteract symptoms of nerve agent intoxication and restore acetylcholinesterase activity. This treatment increases survivalrates after nerve agent exposure, however, seizures resulting from nerve agent poisoning are a common symptom that ca ...

    SBIR Phase I 2019 Department of DefenseOffice for Chemical and Biological Defense
  5. Durable Stretch Barrier Materials

    SBC: LaunchBay LLC            Topic: CBD181003

    Chemical, Biological, Radioactive and Nuclear (CBRN) protective ensembles are widely used by the US Military and civilian first responders asthe first line of defense for personnel working in contaminated environments. Many innovative products have been developed for thechemical protective clothing market in response to demand from the market place for improved performance. However, the need forte ...

    SBIR Phase I 2019 Department of DefenseOffice for Chemical and Biological Defense
  6. Open-Path Spatial Ring Down Spectrometer for Chemical Vapor Detection

    SBC: Physical Sciences Inc.            Topic: CBD171004

    Physical Science Inc. (PSI) will develop a new approach to chemical vapor detection based on a novel open-path sample cell design. The PhaseI system level model predicts SNR supporting a probability of detection of 95% and a MTBFA of 168 hours for all relevant CWAs and TICs at the10 minute negligible MEG level at a 20 s measurement time. In addition to robust detection, the system design can provi ...

    SBIR Phase II 2019 Department of DefenseOffice for Chemical and Biological Defense
  7. Fluorescence Imager for Rapid Estimates of the Distribution and Abundance of Coral Recruits

    SBC: Physical Sciences Inc.            Topic: 831

    New methods are needed to help marine scientists conduct studies of the processes limiting or promoting coral recruitment and survivorship. The small size and low visual contrast of coral recruits in natural settings make them difficult to impossible to locate efficiently. Many coral recruits contain strongly fluorescent pigments, and viewed in the proper way this fluorescence dramatically incre ...

    SBIR Phase II 2004 Department of Commerce
  8. Inexpensive Submersible Long-Term Dissolved Oxygen Recorder

    SBC: Polestar Technologies, Inc.            Topic: 825

    Polestar Technologies, Inc. proposes a Phase II SBIR Project to complete the development of an inexpensive compact optical system for continuous dissolved oxygen monitoring in areas at risk of eutrophication induced by hypoxia and anoxia. The proposed monitor will facilitate the development of improved theoretical models by enabling better data collection with regard to spread and degree of oxyge ...

    SBIR Phase II 2004 Department of Commerce
  9. An Innovative Low-Cost Dropsonde using Integrated Flexible Circuit Design

    SBC: Yankee Environmental Systems, Inc.            Topic: 819

    Upper atmospheric measurements of temperature, humidity, pressure and winds are required daily at hundreds of locations around the world to drive numerical weather prediction forecast models. In the US these critical measurements are made by Radiosondes carried aloft by balloons filled with helium and tracked by 104 NWS ground stations. However, data-sparse regions off the west coast can only be a ...

    SBIR Phase II 2004 Department of Commerce
  10. High Speed Low Loss Optical Switch

    SBC: AGILTRON, INC.            Topic: N/A

    High performance fiberoptic switch is an enable technology for new generation optical telecommunication and fully secured quantum communication/cryptography applications. Current fiberoptic switches do not simultaneously meet the requirements of high speed, low loss, high extinction ratio, and high reliability. Based on the successful development/production of a variety of industrial leading solid ...

    SBIR Phase I 2004 Department of CommerceNational Institute of Standards and Technology

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