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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Microcapillary Quartz Sensors for Screening Injectability of High Concentration Protein Formulations

    SBC: Qatch Technologies, LLC            Topic: None

    The objective of this SBIR Phase I proposal is to determine the feasibility of viscosity characterization of high concentration protein formulations (HCF) by QATCH’s microcapillary quartz technology. HCFs are non-Newtonian fluids with shear-thinning behavior and they are administered to patients by subcutaneous or muscular injections. The injectability of HCFs depends on the viscosity at high-sh ...

    SBIR Phase I 2019 Department of CommerceNational Institute of Standards and Technology
  2. Developing Silicon Nanowire Sensors to Measuring Host-Cell Proteins at a Biomanufacturing Line

    SBC: Advanced Silicon Group            Topic: None

    Our biosensor is made of silicon nanowire arrays functionalized with antibodies to measure the concentration of specific proteins. In this grant we will take a sensor that has been demonstrated for use in measuring a set of generic host cell proteins and we will apply the sensor to measure a set of proteins for a specific cell line. In doing so, we will demonstrate the utility of our sensor to be ...

    SBIR Phase II 2019 Department of CommerceNational Institute of Standards and Technology
  3. Biphase Extended Release Tablet Formulation for Nerve Agent Pretreatment

    SBC: Zymeron Corporation            Topic: CBD181004

    Given the unforeseen/unanticipated use of nerve agents in the battlefield and on the homeland, military personnel can benefit from this oncedaily pretreatment. It may also be desirable to pretreat certain medical and emergency aid personnel following a known/suspected nerveagent attack. Also, a novel, improved PB extended release formulations can be commercialized for the treatment of myasthenia g ...

    SBIR Phase I 2019 Department of DefenseOffice for Chemical and Biological Defense
  4. Dual Formulation of Atropine and Scopolamine with Enhanced Stability

    SBC: Nano Terra, Inc.            Topic: CBD181005

    The standard US military treatment for nerve agent exposure is application of up to three autoinjectors, each containing atropine sulfate and2-pralidoxime, to counteract symptoms of nerve agent intoxication and restore acetylcholinesterase activity. This treatment increases survivalrates after nerve agent exposure, however, seizures resulting from nerve agent poisoning are a common symptom that ca ...

    SBIR Phase I 2019 Department of DefenseOffice for Chemical and Biological Defense
  5. Durable Stretch Barrier Materials

    SBC: LaunchBay LLC            Topic: CBD181003

    Chemical, Biological, Radioactive and Nuclear (CBRN) protective ensembles are widely used by the US Military and civilian first responders asthe first line of defense for personnel working in contaminated environments. Many innovative products have been developed for thechemical protective clothing market in response to demand from the market place for improved performance. However, the need forte ...

    SBIR Phase I 2019 Department of DefenseOffice for Chemical and Biological Defense
  6. Open-Path Spatial Ring Down Spectrometer for Chemical Vapor Detection

    SBC: Physical Sciences Inc.            Topic: CBD171004

    Physical Science Inc. (PSI) will develop a new approach to chemical vapor detection based on a novel open-path sample cell design. The PhaseI system level model predicts SNR supporting a probability of detection of 95% and a MTBFA of 168 hours for all relevant CWAs and TICs at the10 minute negligible MEG level at a 20 s measurement time. In addition to robust detection, the system design can provi ...

    SBIR Phase II 2019 Department of DefenseOffice for Chemical and Biological Defense
  7. Formaldehyde and Hydrogen Peroxide Instrument for Flight Based Measurements

    SBC: Aerodyne Research, Inc.            Topic: 8314

    Hydrogen peroxide formation represents a loss of gas phase HOx and results in the transfer of atmospheric oxidative capacity to the liquid phase. Measurements of formaldehyde and H2O2 are vital to fully elucidate the atmospheric mechanisms associated with ozone formation and the formation of inorganic and secondary organic aerosol throughout the atmosphere. Tunable infrared differential absorpti ...

    SBIR Phase I 2005 Department of Commerce
  8. Predictive Modeling of Solar Insolation in the Marine Environment for Solar Power System Applications

    SBC: Irradiance, Inc.            Topic: 831

    We aim to develop analytic tools and instruments to improve performance predictions for photovoltaic power systems on buoys. Using these capabilities, we can design more powerful and reliable power systems and provide NDBC more power to operate offshore data buoys and serve the Nation with enhanced observations of the marine environment. Present day buoy power systems are feasible because they u ...

    SBIR Phase I 2005 Department of Commerce
  9. Nutrient Sensor for Observing Systems

    SBC: Physical Sciences Inc.            Topic: 814

    Physical Sciences Inc. (PSI) will design an optical sensor to provide a cost-effective and ruggedized solution to the detection of nutrient loading for long deployment periods in the ocean environment. The proposed sensor is based on an existing instrument that has been already been developed and has demonstrated the usefulness of using optical methods to determine the nitrate, nitrite, bisulfide ...

    SBIR Phase I 2005 Department of Commerce
  10. Submersible In-Situ Grain Sizing Device

    SBC: Physical Sciences Inc.            Topic: 8114

    A novel, miniaturized optical sensor for in-situ monitoring of underwater sediment grain size is described. This device employs light scattering measurement techniques previously developed by Physical Sciences, Inc. (PSI) for the U.S. Navy in a compact, powerful tool for acquiring quantitative information on particle size. Combining this innovative, miniature and inexpensive technology with unde ...

    SBIR Phase I 2005 Department of Commerce

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