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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Microcapillary Quartz Sensors for Screening Injectability of High Concentration Protein Formulations

    SBC: Qatch Technologies, LLC            Topic: None

    The objective of this SBIR Phase I proposal is to determine the feasibility of viscosity characterization of high concentration protein formulations (HCF) by QATCH’s microcapillary quartz technology. HCFs are non-Newtonian fluids with shear-thinning behavior and they are administered to patients by subcutaneous or muscular injections. The injectability of HCFs depends on the viscosity at high-sh ...

    SBIR Phase I 2019 Department of CommerceNational Institute of Standards and Technology
  2. Developing Silicon Nanowire Sensors to Measuring Host-Cell Proteins at a Biomanufacturing Line

    SBC: Advanced Silicon Group            Topic: None

    Our biosensor is made of silicon nanowire arrays functionalized with antibodies to measure the concentration of specific proteins. In this grant we will take a sensor that has been demonstrated for use in measuring a set of generic host cell proteins and we will apply the sensor to measure a set of proteins for a specific cell line. In doing so, we will demonstrate the utility of our sensor to be ...

    SBIR Phase II 2019 Department of CommerceNational Institute of Standards and Technology
  3. Biphase Extended Release Tablet Formulation for Nerve Agent Pretreatment

    SBC: Zymeron Corporation            Topic: CBD181004

    Given the unforeseen/unanticipated use of nerve agents in the battlefield and on the homeland, military personnel can benefit from this oncedaily pretreatment. It may also be desirable to pretreat certain medical and emergency aid personnel following a known/suspected nerveagent attack. Also, a novel, improved PB extended release formulations can be commercialized for the treatment of myasthenia g ...

    SBIR Phase I 2019 Department of DefenseOffice for Chemical and Biological Defense
  4. Dual Formulation of Atropine and Scopolamine with Enhanced Stability

    SBC: Nano Terra, Inc.            Topic: CBD181005

    The standard US military treatment for nerve agent exposure is application of up to three autoinjectors, each containing atropine sulfate and2-pralidoxime, to counteract symptoms of nerve agent intoxication and restore acetylcholinesterase activity. This treatment increases survivalrates after nerve agent exposure, however, seizures resulting from nerve agent poisoning are a common symptom that ca ...

    SBIR Phase I 2019 Department of DefenseOffice for Chemical and Biological Defense
  5. Durable Stretch Barrier Materials

    SBC: LaunchBay LLC            Topic: CBD181003

    Chemical, Biological, Radioactive and Nuclear (CBRN) protective ensembles are widely used by the US Military and civilian first responders asthe first line of defense for personnel working in contaminated environments. Many innovative products have been developed for thechemical protective clothing market in response to demand from the market place for improved performance. However, the need forte ...

    SBIR Phase I 2019 Department of DefenseOffice for Chemical and Biological Defense
  6. Open-Path Spatial Ring Down Spectrometer for Chemical Vapor Detection

    SBC: Physical Sciences Inc.            Topic: CBD171004

    Physical Science Inc. (PSI) will develop a new approach to chemical vapor detection based on a novel open-path sample cell design. The PhaseI system level model predicts SNR supporting a probability of detection of 95% and a MTBFA of 168 hours for all relevant CWAs and TICs at the10 minute negligible MEG level at a 20 s measurement time. In addition to robust detection, the system design can provi ...

    SBIR Phase II 2019 Department of DefenseOffice for Chemical and Biological Defense
  7. Surveying Earth's Gravity with Unmanned Aerial Vehicles

    SBC: AURORA FLIGHT SCIENCES CORPORATION            Topic: 912RN

    To assist with the National Geodetic Survey’s federal mandate to provide accurate positioning—including heights—to all federal non-military mapping activities in the USA, Aurora Flight Sciences proposes to integrate a gravimetry payload on a unmanned aerial system (UAS). Potential options include using either an unmanned aerial vehicle (UAV) or an optionally piloted aircraft (OPA). An OPA ...

    SBIR Phase I 2013 Department of CommerceNational Oceanic and Atmospheric Administration
  8. Porous Membrane Electrode for Quantitative Detection of Toxins

    SBC: Mercury Science Inc.            Topic: 816N

    In Phase I, a novel porous electrode was designed to demonstrate a rapid, simple assay for the detection of domoic acid in marine samples. During Phase II, methods to manufacture porous electrodes will be improved to enable high volume production of low-cost biosensors that can be connected to a potentiostat. These biosensors will be incorporated into a portable test kit for the quantitation of do ...

    SBIR Phase II 2013 Department of CommerceNational Oceanic and Atmospheric Administration
  9. Dip and Read Nanosensor for Calcium Ion Measurements in Sea Water

    SBC: Polestar Technologies, Inc.            Topic: 822R

    This topic requires the capability for enabling high sensitivity/high precision measurements of calcium concentrates in seawater. This proposal aims to demonstrate the feasibility of a novel high sensitive nanosensor that can be used to determine very low concentrations of calcium in seawater in the presence of a large background calcium concentration. The sensor approach uses the benefits of nano ...

    SBIR Phase II 2013 Department of CommerceNational Oceanic and Atmospheric Administration
  10. Enhancing the Pharmacokinetic Profile of Protein-based Drugs

    SBC: Extend Biosciences Inc.            Topic: CBD12101

    Many protein-based drugs have limited efficacy due to a short half-life or require intravenous delivery because of low bioavailability when given subcutaneously. Extend Biosciences is developing proprietary carrier molecules that will allow proteins to access a transport pathway for efficient delivery to the vascular space and then maintain a sustained presence in circulation. This would be of par ...

    SBIR Phase I 2013 Department of DefenseOffice for Chemical and Biological Defense

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