Award Data

Internal Combustion engines (IC) are bound in their ability to create power primarily by the volume of air an engine is able to deliver to the combustion chamber. This formula has particular import at high altitude, where air pressure decreases, resulting in a correlative power loss. Traditional solutions for generating higher compensating air pressure are limited to external add-on devices such ...

Insensitive munitions (IM) design and testing for propulsion systems is hindered both by high test costs and the complexity of propellant responses to IM stimuli. Modeling and simulation tools for predictions of IM hazards are under development that characterize many of the pertinent phenomena, including damage sensitization to reaction and delayed-onset detonation. Such tools can provide many b ...

Viral vectors are used in more than 70% of current gene therapy trials. However, immunogenicity, oncogenicity, and poor tumor transfection efficiencies present significant barriers to clinical success. Sleeping Beauty Transposon (SBT) technology, combined with a targeted, tumor-penetrating, non-viral gene transfer system, offers an alternative approach for therapeutic transgene production with lo ...

The pressing need exists within industry to accurately measure high aspect ratio microscale structures. For example, diesel injector nozzles are manufactured with microscale holes ranging from 50-200 micrometers in diameter and 3-5 mm depths. One fundamental challenge is to nondestrucvely measure these features in order to validate models, enhance manufacturing processes, and reduce fuel emissions ...

Manning Applied Technology proposes to develop a handheld infrared spectrometer, ideally suited to detection of airborne chemical agents at and below permissible exposure limits. This approach offers unmatched sensitivity and specificity for detection of all types of chemical vapors. The instrument is modular, rugged, compact and highly sensitive. Volume pricing will be less than $1000 each. ...

Flax containing omega 3 fatty acids and relatively high protein content offers advantages as a potential source of plant protein and oil to replace fishmeal and oil in aquaculture feeds; reducing both pressure on marine fisheries and the principal source of contaminants in farmed fish. MMP ahs used innovative fungal culture technology in separate processes to develop low cost, multi activity cell ...

This Phase I proposal is aimed to develop a technology to delivery lipophilic therapeutic ingredients in broad and antimalarial drug primaquine in specific through skins. The proposed driving force of delivering target drugs is the opposite chemical affiliation of storage copolymer matrix and active therapeutic ingredient. The technology includes the formulation of patches - hydrophilic polymers, ...

This Phase I SBIR program will design and manufacture a unique anti-tamper device determines when adversarial acquisition or exploitation of U.S. analog and/or digital circuit components has been made by monitoring circuit activity. The sensor operates as a sensitive switch. The state of the switch is determined by the configuration of an array of lithographically defined magnetic elements. If ...

Maintenance on Army Tactical Power Systems (TPS's) is currently performed at regular intervals regardless of actual usage or operating conditions - wasting resources servicing systems that do not need maintenance, and missing opportunities to prevent catastrophic failures. The Army seeks to 1) improve maintenance efficiency and effectiveness by servicing systems based on actual usage and 2) imple ...

Infection in areas of bone injury are a serious consideration in the field of trauma surgery and orthopaedic medicine. The combination of regenerative medicine and controlled drug delivery offers great potential to improve on the current standard of care. Presently, bone infection secondary to osteomyelitis and non-union are treated in a two-stage protocol wherein the first step requires placeme ...