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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Nanodroplet PCR Lab-Chip for Clinical Pathogen Detection

    SBC: ADVANCED LIQUID LOGIC            Topic: N/A

    DESCRIPTION (provided by applicant): Rapid and accurate detection and identification of pathogens is crucial for the effective management and treatment of infectious disease. While molecular diagnostic techniques including PCR are a promising approach for rapid and sensitive detection of pathogens, they suffer from a number of technical drawbacks which have slowed their acceptance in the clinic. ...

    SBIR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
  2. Discovery of Peptide-based Bone Morphogenic Protein Mimetics

    SBC: AFFINERGY, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): In this proposal, we present a novel approach for the identification and immobilization of a BMP mimetic. We plan to use phage display technology to identify peptides that mimic BMP-like signaling of the BMP receptors. These peptides will be linked to a previously identified high-affinity, collagen-binding peptide. The resulting hybrid molecule will allow contr ...

    SBIR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
  3. Improved Orthopedic Implant Surface Coatings

    SBC: AFFINERGY, LLC            Topic: N/A

    Endosseous metallic implants are common alloplastic devices used in medicine and dentistry. The orthopedic and dental marketplace continues to grow and indications for implants are expanding. There is a perceived need to improve both the successful healing (osseointegration) and the long term outcome of implants by control of interfacial reactivity during healing and remodeling. The growth of know ...

    SBIR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
  4. Electrochemical RT activity assay for measuring HIV load

    SBC: ALDERON BIOSCIENCES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): In this Phase I SBIR project Alderon Biosciences Inc. (ABI) proposes to demonstrate the feasibility of using electrochemical reverse transcriptase (eRT) assays for determinations of HIV viral load in clinical samples. Success will set the stage for Phase II development, FDA approval, and production of commercial kits using this advanced technology. The long-r ...

    SBIR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
  5. Electrochemical Quantification of HCV RNA

    SBC: ALDERON BIOSCIENCES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The National Institutes of Allergy and Infectious Disease have called for better tools for the detection and diagnosis of emerging and re-emerging infectious diseases. To meet this need, Alderon Biosciences Inc. (ABI) proposes to develop innovative, low-cost tests with sensitivity adequate for determining HCV viral load. Reliable and affordable HCV viral load t ...

    SBIR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
  6. rAAV Revitalized Structural Allografts

    SBC: ASKLEPIOS BIOPHARMACEUTICAL, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Repair of large structural bone defects remains a major problem in orthopaedic reconstruction surgery due to the limited supply of cortical bone autograft and the poor long-term outcomes obtained with structural allografts. While there is no substitute for structural allografts, based on their biomechanical and biocompatible properties, their lack of osteogenic ...

    SBIR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
  7. Stability of new, iron-replete total nutrient admixtures

    SBC: BIOLINK LIFE SCIENCES INC            Topic: N/A

    DESCRIPTION (provided by applicant): There has been little progress in the treatment of iron deficiency anemia using a parenteral nutrient (PN) admixture with lipids as a suitable drug delivery vehicle. Currently approved parenteral iron colloids (e.g., iron dextrans) destabilize total nutrient admixtures with lipids and also present safety risks to the patient. This project will assess the safety ...

    SBIR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
  8. Diffuse spectroscopy for inhomogeneous metal nanoparticle assays

    SBC: CENTICE CORPORATION            Topic: N/A

    DESCRIPTION (provided by applicant): Centice proposes to develop a compact computational spectroscopy platform optimized for molecular recognition using metal nanoparticle assays. Nanoparticle based sensing mechanisms have been successfully demonstrated for the diagnosis and monitoring of diseases, drug discovery, proteomics and biological agent detection. Molecular binding on the nanoparticle sur ...

    SBIR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
  9. New Thalidomide Analogs for Retinal Neovacularization

    SBC: Charlesson, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Diabetic retinopathy is a common complication of diabetes mellitus and a leading cause of blindness in the developed countries. There are two major pathological changes which impair vision in diabetic retinopathy: diabetic macular edema (DME) resulting from increased retinal vascular permeability and abnormal angiogenesis in the retina or retinal neovasculariz ...

    SBIR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
  10. Peptide Eyedrops for Treatment of Diabetic Retinopathy

    SBC: Charlesson, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Diabetic retinopathy is a common complication of diabetes and a leading cause of blindness in the US and the world. Diabetic macular edema (DME) and retinal neovascularization are the two major pathological alternations leading to the vision loss in diabetic retinopathy. The retinal vascular hyper-permeability or vascular leakage is primarily responsible for DM ...

    SBIR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
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