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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Microcapillary Quartz Sensors for Screening Injectability of High Concentration Protein Formulations

    SBC: QATCH TECHNOLOGIES LLC            Topic: None

    The objective of this SBIR Phase I proposal is to determine the feasibility of viscosity characterization of high concentration protein formulations (HCF) by QATCH’s microcapillary quartz technology. HCFs are non-Newtonian fluids with shear-thinning behavior and they are administered to patients by subcutaneous or muscular injections. The injectability of HCFs depends on the viscosity at high-sh ...

    SBIR Phase I 2019 Department of CommerceNational Institute of Standards and Technology
  2. Gap-Free Model-Based Engineering for Manufacturing and Analysis: Digital Thread without Translation

    SBC: Nvariate, Inc.            Topic: None

    Modern Model-Based Enterprise / Engineering (MBE) systems rely on freeform surfaces built as complex combinations of geometric primitives to define engineered objects. Unfortunately, the intersection of freeform surfaces in MBE applications results in highly approximated solutions, degrading models that cost billions annually by US industry to fix. Current technology limits the abilities of users ...

    SBIR Phase I 2019 Department of CommerceNational Institute of Standards and Technology
  3. Advanced Manufacturing and Material Measurements Software Tool Weave ™ for the Acceleration and Automation of SEM Image Analysis in the Semiconductor Industry

    SBC: Sandbox Semiconductor Incorporated            Topic: None

    In this Phase I SBIR proposal, SandBox Semiconductor™ proposes to develop an Advanced Manufacturing and Material Measurements software tool called Weave ™ for accelerating and automating SEM image analysis for the semiconductor industry. During the development of a new manufacturing process line for a semiconductor device, tens of thousands of scanning electron microscopy (SEM) images are take ...

    SBIR Phase I 2019 Department of CommerceNational Institute of Standards and Technology
  4. Biphase Extended Release Tablet Formulation for Nerve Agent Pretreatment

    SBC: ZYMERON CORP            Topic: CBD181004

    Nerve agents exert their toxic effect by binding to and inactivating enzyme acetylcholinesterase, a key enzymatic regulator of cholinergic neurotransmission. The binding becomes irreversible after a varying amount of time with nerve agents and this aging process limits the treatment window of oxime reactivators. To enhance the current antidote treatment of nerve agent autoinjectors, a pyridostigmi ...

    SBIR Phase I 2019 Department of DefenseOffice for Chemical and Biological Defense
  5. Bi-specific Antibodies Targeting Disease Caused by Encephalitic Alphaviruses

    SBC: BRHMS LLC            Topic: CBD181007

    Highly pathogenic alphaviruses like VEEV/EEV/WWEEV cause encephalitis in humans and equids. These infections are endemic in wide regions of the developing world. Translational research regarding these pathogens is focused on developing new strategies to detect, treat and ideally protect humans and animals from these infections. Gene-encoded antibodies against alphavirus E1/E2 surface proteins will ...

    SBIR Phase I 2019 Department of DefenseOffice for Chemical and Biological Defense
  6. Self-Detoxifying, Disposable Protective Garments

    SBC: LYNNTECH INC.            Topic: CBD06108

    There are many types of limited use or disposable protective garments and apparel designed to inhibit/retard the passage of hazardous liquids and biological contaminates through the garment to the wearer. The current state-of-the-art Chem-Bio protective suits contain carbon-beads layered into textile materials which adsorb toxic liquids and vapors. However, activated carbon imparts only partial p ...

    SBIR Phase I 2006 Department of DefenseOffice for Chemical and Biological Defense
  7. Reagentless and Realtime Detection of Airborne Microorganisms

    SBC: LYNNTECH INC.            Topic: CBD06102

    The potential use of chemical and biological weapons for mass destruction is one of the most serious concerns facing the US defense forces. Currently available devices for collection and identification of biological agents require extensive sample preparation and well equipped laboratories. Other detection methods rely on fragile biomolecules like antibodies, nucleic acids, enzymes and/or other ...

    SBIR Phase I 2006 Department of DefenseOffice for Chemical and Biological Defense
  8. User-Friendly 3D Environmental Profiler AUV

    SBC: NEKTON RESEARCH LLC            Topic: 813

    We propose Ranger ES, a low cost, autonomous underwater vehicle (AUV) for three-dimensional profiling and water samplings of chemical, physical, and biological parameters of oceanic and fresh waters. The AUV will be programmable by point and click to analyze a volume of water continuously for the selected parameters. After returning for pickup after a day¿s run, it will download its data into a ...

    SBIR Phase I 2006 Department of Commerce
  9. FRET-Aptamer Assays & Handheld Reader for Nerve Agent Metabolites

    SBC: Operational Techologies Corporation            Topic: CBD06104

    Operational Technologies Corporation (OpTech) proposes to couple the speed and ultrasensitivity of one-step (“bind and detect”) fluorescence resonance energy transfer (FRET) detection with the high affinity and selectivity of DNA aptamers (surrogate antibodies) to detect the phosphonic acid derivative metabolites of organophosphorous nerve agents in urine, blood, and other body fluids. In Pha ...

    SBIR Phase I 2006 Department of DefenseOffice for Chemical and Biological Defense
  10. Construction of a Force Probe for Characterization of Microscale Features

    SBC: INSITUTEC, INC.            Topic: N/A

    The pressing need exists within industry to accurately measure high aspect ratio microscale structures. For example, diesel injector nozzles are manufactured with microscale holes ranging from 50-200 micrometers in diameter and 3-5 mm depths. One fundamental challenge is to nondestrucvely measure these features in order to validate models, enhance manufacturing processes, and reduce fuel emissions ...

    SBIR Phase I 2005 Department of CommerceNational Institute of Standards and Technology
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