Award Data

The objective of this SBIR Phase I proposal is to determine the feasibility of viscosity characterization of high concentration protein formulations (HCF) by QATCH’s microcapillary quartz technology. HCFs are non-Newtonian fluids with shear-thinning behavior and they are administered to patients by subcutaneous or muscular injections. The injectability of HCFs depends on the viscosity at high-sh ...

Electro-optical infrared and long wavelength infrared detectors and sensors are increasingly important for the Chemical/Biological Defense community. Solid-state optical cooler materials are in demand for replacing mechanical closed cycle coolers used in current LWIR standoff sensors to achieve cryogenic temperatures. Recent advances in optical cooling of rare-earth doped materials are pointing to ...

The proliferation of weapons of mass destruction (WMDs) presents a serious security threat to U.S. and allied personnel around the world. Military personnel and first responders must be prepared to operate under a wide range of chemical, biological, radiological, nuclear (CBRN) threats. Commercially available CBRN protective suits are bulky offering little dexterity to the wearer, therefore new st ...

In response to the defined need for minimizing the carry weight of combat teams while retaining capability, Luna Innovations is proposing the development of a stable formulation of atropine and scopolamine for use in an autoinjector to combat nerve agent intoxication. The combined formulation of atropine and scopolamine will allow for better treatment with more physiological coverage within the hu ...

Nerve agents exert their toxic effect by binding to and inactivating enzyme acetylcholinesterase, a key enzymatic regulator of cholinergic neurotransmission. The binding becomes irreversible after a varying amount of time with nerve agents and this aging process limits the treatment window of oxime reactivators. To enhance the current antidote treatment of nerve agent autoinjectors, a pyridostigmi ...

The pressing need exists within industry to accurately measure high aspect ratio microscale structures. For example, diesel injector nozzles are manufactured with microscale holes ranging from 50-200 micrometers in diameter and 3-5 mm depths. One fundamental challenge is to nondestrucvely measure these features in order to validate models, enhance manufacturing processes, and reduce fuel emissions ...

Manning Applied Technology proposes to develop a handheld infrared spectrometer, ideally suited to detection of airborne chemical agents at and below permissible exposure limits. This approach offers unmatched sensitivity and specificity for detection of all types of chemical vapors. The instrument is modular, rugged, compact and highly sensitive. Volume pricing will be less than $1000 each. ...

The cost-effective manufacturing of a novel algaecide against blue green algae in fresh-water aquaculture operations has great potential for controlling ¿off-flavor¿ problems in pond-raised catfish. The proposed natural-based algaecide has selective activity for blue-green algae as well as a more favorable environmental performance profile with little/no activity towards complimentary phytoplan ...

Open Tech proposes to develop a fully extensible collaborative tools framework that combines powerful features, and intuitive user interface, and the ability to easily implement new and imaginative object interaction techniques. The tools will allow users of both local and remote immersive VE systems to join together in a single shared VE that allows them to interact with each other and with objec ...

Recent developments in the world political arena have led to The need for miniaturized instrumentation for rapid characterization of micro-organisms and toxins to protect military and civilian personnel against biological weapons and to allow timely administration of prophylactics. Considerable effort is currently underway to develop polymerase chain reaction (PCR) assays with automated samp ...