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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. A Novel Microfludic Device for Drug Toxicity Studies

    SBC: CFD Research Corporation            Topic: CBD10103

    Current drug discovery and development programs are severely limited by the expensive animal trials and oversimplified in vitro models. Results obtained from the in vitro models are not predictive of in vivo toxicity owing to significant difference in testing from the in vivo physiological conditions. In this context, we propose to develop and demonstrate a novel microfluidic device for quantitati ...

    SBIR Phase I 2010 Department of DefenseOffice for Chemical and Biological Defense
  2. Microfluidic High-throughput Platform for Determining of Kinetic Constants of Enzyme Variants

    SBC: CFD Research Corporation            Topic: CBD10107

    Molecular biology techniques allow generating combinatorial libraries of large number of enzyme variants. However, there is currently no technology available for screening the enzyme libraries for identifying variants with improved activity for the substrate. We propose to develop a novel, microfluidic, high-throughput platform for determining kinetic constants of enzyme variants and identifying v ...

    SBIR Phase I 2010 Department of DefenseOffice for Chemical and Biological Defense
  3. Novel MicroPower Source for Insect Based Sensor and Communication Platforms

    SBC: CFD Research Corporation            Topic: CBD09105

    Our objective is to develop a novel micropower source to be integrated with a microsensor, and communication chip on an insect, delivering a state-of-the-art unmanned chemical detection device. The biological fuel cell (Bio-FC) power source will leverage ongoing research at CFDRC and provide a compact/lightweight power supply for mounting on numerous types of insects and producing necessary power ...

    SBIR Phase II 2010 Department of DefenseOffice for Chemical and Biological Defense
  4. Ground-based Water Vapor Profiling Lidar

    SBC: Bennett Aerospace, Inc.            Topic: 832

    The objective of Phase II is to continue our efforts from the Phase I project and perform in-depth testing of technologies critical to achieving the required level of measurement performance. The Phase II project will involve the design of the NOAA water vapor profiling lidar and testing of component parts, seeking external sources of funding for the systems (for Phase III) and further creating a ...

    SBIR Phase II 2010 Department of Commerce
  5. Creating Resilient Structures with Polymer Coatings

    SBC: Optechnology, Inc.            Topic: 819S

    The first goal of our team is to design and develop highly ductile cement mortar composites using novel patent applied for technology which has been shown to produce materials with high energy absorption, decreased modulus, higher tensile strength, and greater toughness than standard or ultra high performance concretes or fibercements. These materials will be used to produce NEMA Class 5 flood res ...

    SBIR Phase II 2010 Department of Commerce
  6. CBRN Sensor and Sensor Netting Algorithms

    SBC: Torch Technologies, Inc.            Topic: CBD09110

    information) During Phase I the Torch Technologies developed, demonstrated, and assessed the feasibility of an innovative, real-time multi-layered CW sensor data fusion network capability supporting advanced standoff detection and early warning against CB threats. Torch merged two significant technologies that we developed for the Department of Defense: 1) the ACRES CW multi-sensor data fusion t ...

    SBIR Phase II 2010 Department of DefenseOffice for Chemical and Biological Defense
  7. Analysis Tools for Detection and Diagnosis of Biological Threats

    SBC: ALPHA-GAMMA TECHNOLOGIES, INC.            Topic: CBD04113

    DNA microarray technology, in combination with statistical and predictive modeling tools, could be used to evaluate thousands of genes against distinct gene expression patterns induced by chemical/biological agents to provide early identification and speed therapeutic intervention. The overall objective of this Phase II effort is to leverage existing public domain resources and commercial tools t ...

    SBIR Phase II 2005 Department of DefenseOffice for Chemical and Biological Defense
  8. Construction of a Force Probe for Characterization of Microscale Features

    SBC: INSITUTEC, INC.            Topic: N/A

    The pressing need exists within industry to accurately measure high aspect ratio microscale structures. For example, diesel injector nozzles are manufactured with microscale holes ranging from 50-200 micrometers in diameter and 3-5 mm depths. One fundamental challenge is to nondestrucvely measure these features in order to validate models, enhance manufacturing processes, and reduce fuel emissions ...

    SBIR Phase I 2005 Department of CommerceNational Institute of Standards and Technology
  9. Handheld Photoacoustic Chemical Agent and Toxic Industrial Material Detector

    SBC: MANNING APPLIED TECHNOLOGY            Topic: CBD05112

    Manning Applied Technology proposes to develop a handheld infrared spectrometer, ideally suited to detection of airborne chemical agents at and below permissible exposure limits. This approach offers unmatched sensitivity and specificity for detection of all types of chemical vapors. The instrument is modular, rugged, compact and highly sensitive. Volume pricing will be less than $1000 each. ...

    SBIR Phase I 2005 Department of DefenseOffice for Chemical and Biological Defense
  10. Hermetic Textile Closure Hardware System

    SBC: SIGMA K CORP            Topic: CBD04110

    Effective collective protection fabrics must have a reliable closure system. During our Phase I Work Plan, Sigma-K began developing a Hermetic Textile Closure Hardware (HATCH) system. The HATCH combines both a magnetic and geometric self locking mechanism that will provide a hermetic seal when closed. Our current Phase I successes include developing self closing samples that can provide a hermetic ...

    SBIR Phase II 2005 Department of DefenseOffice for Chemical and Biological Defense
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