Award Data

The objective of this SBIR Phase I proposal is to determine the feasibility of viscosity characterization of high concentration protein formulations (HCF) by QATCH’s microcapillary quartz technology. HCFs are non-Newtonian fluids with shear-thinning behavior and they are administered to patients by subcutaneous or muscular injections. The injectability of HCFs depends on the viscosity at high-sh ...

Our biosensor is made of silicon nanowire arrays functionalized with antibodies to measure the concentration of specific proteins. In this grant we will take a sensor that has been demonstrated for use in measuring a set of generic host cell proteins and we will apply the sensor to measure a set of proteins for a specific cell line. In doing so, we will demonstrate the utility of our sensor to be ...

Poor air quality represents a major public health risk, contributing to an estimated one of every eight deaths worldwide. Low-cost air quality sensors have developed rapidly over the last few years and offer the opportunity to make air quality monitoring widespread at an affordable price. However, low-cost sensors are currently unable to deliver accurate, reliable data due to a lack of understandi ...

Triton Systems, Inc. proposes development of the Open-Source Oceanographic Asset Recovery Beacon (OpenORB) that will allow the deployment of coastal instrumentation moorings with affordable protection against loss. This open-source kit would significantly reduce the purchase price of a commercial location beacon by allowing the end-user to assemble a customized system with minimal time and effort. ...

In Phase I, we developed a prototype instrument for counting, sizing and identifying both non-toxic and toxic Harmful Algal Bloom (HAB) species. We did this by integrating three innovative technologies: High-throughput color, Light Field Imaging Flow Cytometry to acquire morphological information for each cell, Raman spectroscopy to acquire species-specific molecular information on pigments and tr ...

The recent emergence of the Silicon Drift detector (SDD), for use in energy dispersive x-ray spectrometry (EDS), has made possible x-ray event streams with count rates as high as 1-10 Mcps. A problem with existing digital signal processing, as applied to SDDs, is the significant presence of coincidence peaks above the x-ray background. These coincidence peaks occur with amplitudes comparable to lo ...

Leveraging Agiltron¿s recent breakthrough in the broad band and tunable photonic high-Q factor RF filtering technique, we propose to develop a high-spectral-purity, low-phase-noise, spurs-free opto-electronic oscillator (OEO) operating at W-band for the NIST applications. Based on our unique technical approach and successful development in low loss fiber optics, RF photonic components/modules, an ...

Proposed here is the continued development of an innovative rheometer configuration design at NIST. It describes the determination of suitable detection, drive, control, software and assembly designs for a commercially viable, fully integrated device. The initial efforts will concentrate on examining the sub-systems of the design. An important feature of the proposed strategy is early commercial i ...

Carbon nanotubes are one of the most studied and potentially useful nanoparticles known. However, presently even the purest are only commercially available in mixtures of chiralities and lengths. Even though numerous lab scale methods to separate them have been demonstrated, few offer the potential to be scaled and offered as a product. Eikos has found that, for many applications, nanotube length ...

NOAA supports over 25,000 underwater dive programs per year. To increase the duration and depth of these dives, the use of closed circuit mixed gas rebreathers (CCRs) is being considered. As there currently are no sensors to detect CO2 levels in the breathing gas, Giner, Inc. proposes to continue development of an electrochemical CO2 sensor for CCR use. The technical innovation is the use of a ...