Award Data

DNA microarray technology, in combination with statistical and predictive modeling tools, could be used to evaluate thousands of genes against distinct gene expression patterns induced by chemical/biological agents to provide early identification and speed therapeutic intervention. The overall objective of this Phase II effort is to leverage existing public domain resources and commercial tools t ...

A high sensitivity laser-induced incandescence system is proposed for the detailed characterization of environmental soot. Specifically, innovative approaches have been proposed to (1) reduce the lower detection limit of soot volume fraction and increase the overall measurement range by an order of magnitude from what is currently achievable, and (2) provide PM particle size and number density mea ...

The pressing need exists within industry to accurately measure high aspect ratio microscale structures. For example, diesel injector nozzles are manufactured with microscale holes ranging from 50-200 micrometers in diameter and 3-5 mm depths. One fundamental challenge is to nondestrucvely measure these features in order to validate models, enhance manufacturing processes, and reduce fuel emissions ...

Manning Applied Technology proposes to develop a handheld infrared spectrometer, ideally suited to detection of airborne chemical agents at and below permissible exposure limits. This approach offers unmatched sensitivity and specificity for detection of all types of chemical vapors. The instrument is modular, rugged, compact and highly sensitive. Volume pricing will be less than $1000 each. ...

One of the standard analytical tools on almost all electron microscopes (EM) is an energy dispersive x-ray spectroscopy (EDS) detector used for chemical analysis. However, there are many limitations with the current generation of EDS detectors for EM. The best potential for achieving larger detector active areas, superb energy resolution and an order of magnitude higher count rate compared with co ...

Effective collective protection fabrics must have a reliable closure system. During our Phase I Work Plan, Sigma-K began developing a Hermetic Textile Closure Hardware (HATCH) system. The HATCH combines both a magnetic and geometric self locking mechanism that will provide a hermetic seal when closed. Our current Phase I successes include developing self closing samples that can provide a hermetic ...

Redondo Optics Inc. (ROI), a world leader in engineering and manufacturing of leading-edge nano-materials, optical sensors, fiber and integrated optics, and advanced photonics instrumentation proposes to develop and demonstrate for the first time the concept of an etch-less, deep-UV, fully continuously variable attenuated-phase-shifted mask (ConvaPSMT) technology to enable ultra-high resolution, o ...

DNA microarray technology, in combination with statistical and predictive modeling tools, could be used to evaluate thousands of genes against distinct gene expression patterns induced by chemical/biological agents to provide early identification and speed therapeutic intervention. The overall objective of this proposal is to demonstrate the feasibility of building a data management system for DN ...

In the wake of the September 11th attacks and subsequent Anthrax scares, researchers worldwide are working to expand our ability to rapidly assess what poses a terrorism threat to the public. The rapid detection of specific pathogens is required for biod

Bioren's technology provides an efficient, automated, in vitro system to generate and optimize antibodies and antibody fragments through a rational, hypothesis-driven approach. Bioren's patented technology is based on synthetic oligonucleotide chemistry to create defined antibody mutations. Hypotheses regarding the impact of a specific amino acid's side-chain chemistry within the antigen binding ...