Award Data

The goal of this proposal is find novel combinations of approved drugs for the treatment and/or prevention of infection with filoviruses. Ebola and Marburg viruses, the only filoviruses, cause an acute hemorrhagic fever syndrome which has a high mortality rate and poses a significant bio-terrorism threat. There are currently no therapeutic agents available to treat filovirus infections and the de ...

The development of a generalized moving body capability for Computational Fluid Dynamics (CFD) flow simulations of highly transient flowfields is critical to system analyses of Divert and Attitude Control Systems (DACS) for Kinetic Warheads (KWs). Testing capabilities are limited in the DACS operating regime; therefore, computational tools are essential for such analyses. The flow in the DACS its ...

79108S DNA and protein chip microarray technology relies upon fluorescent labels to visualize DNA hybridization and antigen/antibody binding. A recent breakthrough at Oak Ridge National Laboratory has demonstrated the possibility of label-free detection of DNA hybridization using a microcantilever as the "chip reader." A label-free analyte sensing system would: (1) solve the problem with photob ...

This proposal deals with new techniques for the guidance and control of Boost Phase of the missile defense. A new concept integrating the synergy between guidnace and coontrol is offered as an Integrated Guidance and Control approach; furthermore, a new nonlinear controller-filter called the theta-D technique is offered as the tool to solve the boost phase guidance and control problem for accurate ...

78617S The DOE is interested in reducing the emission of particulate matter in gaseous effluent from both thermal and non-thermal treatment facilities, including coal-fired power plants, incinerators, metals manufacturing, chemical plants, and nuclear treatment facilities. Progress in this area will require the development of instruments to monitor the mass and composition these particulates. T ...

Manning Applied Technology proposes to develop a handheld infrared spectrometer, ideally suited to detection of airborne chemical agents at and below permissible exposure limits. This approach offers unmatched sensitivity and specificity for detection of all types of chemical vapors. The instrument is modular, rugged, compact and highly sensitive. Volume pricing will be less than $1000 each. ...

78845S The Department of Energy desires to increase fuel efficiency by reducing vehicle weight. Carbon fiber composites offer one promising way to do this, but difficulties in building economical, consistent, high quality preforms has limited the introduction of this material. This project will to adapt a well established pulp molding technology to produce carbon fiber preforms for lightweight ...

79454S Despite advances in modern electron optics, which have permitted observation with unprecedented resolutions, most materials science research involves the quantification of static properties of materials. This is mostly due to limitations in modern day equipment and the time and cost associated with modifying existing microscopes. Consequently a need exists to extend the current ability t ...

79658B The reliable fabrication of high performance point electron sources is required for scanning transmission electron microscopy (STEM) systems with brightness greater than 109 Amp/cm2/steradian at an extraction voltage of 100 kV. Conventional point sources require a high vacuum for stable operation, and tip failure occurs by vacuum arcing and unstable emission due to atom migration. This p ...

79658B The reliable fabrication of high performance point electron sources is required for scanning transmission electron microscopy (STEM) systems with brightness greater than 109 Amp/cm2/steradian at an extraction voltage of 100 kV. Conventional point sources require a high vacuum for stable operation, and tip failure occurs by vacuum arcing and unstable emission due to atom migration. This p ...