Award Data

DNA microarray technology, in combination with statistical and predictive modeling tools, could be used to evaluate thousands of genes against distinct gene expression patterns induced by chemical/biological agents to provide early identification and speed therapeutic intervention. The overall objective of this Phase II effort is to leverage existing public domain resources and commercial tools t ...

Manning Applied Technology proposes to develop a handheld infrared spectrometer, ideally suited to detection of airborne chemical agents at and below permissible exposure limits. This approach offers unmatched sensitivity and specificity for detection of all types of chemical vapors. The instrument is modular, rugged, compact and highly sensitive. Volume pricing will be less than $1000 each. ...

Effective collective protection fabrics must have a reliable closure system. During our Phase I Work Plan, Sigma-K began developing a Hermetic Textile Closure Hardware (HATCH) system. The HATCH combines both a magnetic and geometric self locking mechanism that will provide a hermetic seal when closed. Our current Phase I successes include developing self closing samples that can provide a hermetic ...

Redondo Optics Inc. (ROI), a world leader in engineering and manufacturing of leading-edge nano-materials, optical sensors, fiber and integrated optics, and advanced photonics instrumentation proposes to develop and demonstrate for the first time the concept of an etch-less, deep-UV, fully continuously variable attenuated-phase-shifted mask (ConvaPSMT) technology to enable ultra-high resolution, o ...

"The DNA microarray is a powerful new technology that can be applied to the detection of biological warfare agents. For the detection of multiple agents, tremendous challenges lie ahead for the DNA microarray technology regarding on sensitivity,selectivity, reliability and consistence. The central theme of this proposal is to apply and optimize a newly developed DNA probe: Molecular beacons (MB) ...

"Wearable, passive detectors for toxic industrial chemicals (TICs) and chemical warfare agents (CWAs) will greatly improve the safety of military personnel operating in chemically-threatened environments. Cyrano Sciences, Inc. (CSI) uses polymer-compositesensor technology to construct sensor arrays, that are uniquely positioned to address applications, such as detector badges for TICs and CWAs, t ...

"Widespread concern about the prospects of chemical assaults has raised demand for a miniature low-power high resolution wideband spectroscopic sensor for real-time characterization and identification of chemical agent clouds and vapors. Current devicesonly cover narrow bandwidths, and hence require multiple modules to cover the UV, visible, and near IR spectral bands, increasing system weight, s ...

We propose a new type of military smoke that is based on the optical properties of selectively designed, yet low cost, fabricated nanoscale components. These smokes will have a strong extinction in the visible and infrared regions of the spectra, but canalso selectively block or let pass specific wavelengths of light. Such a smoke can be designed to have a field-selectable transmissive window th ...

"This project proposes to cost effectively prepare scFv or Fab antibody fragments that have been modified to site-specifically incorporate stable linkable moieties that will allow their conjugation to reporter molecules and surfaces without comprising thebiological function of the binding site of the antibody fragment. The ready availability of technologies to prepare these antibody fragments wit ...

The objective of the Phase II program is to develop, demonstrate, and integrate a robust and efficient optical parametric oscillator wavelength converter with the Manportable Sensor developed under a prior program. The converter will be based on robustnonlinear crystals in novel intracavity and extracavity resonator configurations that will provide improved conversion efficiency. The effort will i ...