Award Data

DNA microarray technology, in combination with statistical and predictive modeling tools, could be used to evaluate thousands of genes against distinct gene expression patterns induced by chemical/biological agents to provide early identification and speed therapeutic intervention. The overall objective of this Phase II effort is to leverage existing public domain resources and commercial tools t ...

Manning Applied Technology proposes to develop a handheld infrared spectrometer, ideally suited to detection of airborne chemical agents at and below permissible exposure limits. This approach offers unmatched sensitivity and specificity for detection of all types of chemical vapors. The instrument is modular, rugged, compact and highly sensitive. Volume pricing will be less than $1000 each. ...

Effective collective protection fabrics must have a reliable closure system. During our Phase I Work Plan, Sigma-K began developing a Hermetic Textile Closure Hardware (HATCH) system. The HATCH combines both a magnetic and geometric self locking mechanism that will provide a hermetic seal when closed. Our current Phase I successes include developing self closing samples that can provide a hermetic ...

Redondo Optics Inc. (ROI), a world leader in engineering and manufacturing of leading-edge nano-materials, optical sensors, fiber and integrated optics, and advanced photonics instrumentation proposes to develop and demonstrate for the first time the concept of an etch-less, deep-UV, fully continuously variable attenuated-phase-shifted mask (ConvaPSMT) technology to enable ultra-high resolution, o ...

DNA microarray technology, in combination with statistical and predictive modeling tools, could be used to evaluate thousands of genes against distinct gene expression patterns induced by chemical/biological agents to provide early identification and speed therapeutic intervention. The overall objective of this proposal is to demonstrate the feasibility of building a data management system for DN ...

In the wake of the September 11th attacks and subsequent Anthrax scares, researchers worldwide are working to expand our ability to rapidly assess what poses a terrorism threat to the public. The rapid detection of specific pathogens is required for biod

Bioren's technology provides an efficient, automated, in vitro system to generate and optimize antibodies and antibody fragments through a rational, hypothesis-driven approach. Bioren's patented technology is based on synthetic oligonucleotide chemistry to create defined antibody mutations. Hypotheses regarding the impact of a specific amino acid's side-chain chemistry within the antigen binding ...

Light-weight, high-performance subcomponents, particularly filters and pumps, are needed to make a portable water purifier that can produce clean water from any source. At present, some of the principal problems that hamper this effort include the heavy weight of the pumps and their motors and the large size and fouling rate of pre-treatment filters. These problems may be overcome using Los Gato ...

The threat of bioterrorism has increased the demand for advanced technologies to rapidly and accurately detect and identify numerous pathogens at the species and strain level in air, water, food and other matrices. Advanced automated instrumentation with low operating costs that can be rapidly adaptable to new pathogens or agents is required. This proposal describes rapid application of microflu ...

PCR and antibody-based devices are currently the primary platforms for bioagent detection. PCR offers high sensitivity and specificity, but has limited effectiveness for toxins (detects residual DNA, if any, in toxin preparations) and requires thermal cycling equipment, extensive sample preparation, and complex reagents. Antibodies, which utilize relatively simple chemistry, are effective for bo ...