Award Data

Organophosphorus (OP) compounds have been extensively used as pesticides and chemical warfare agents . Potential OPs exposure exists both on the battlefield and in the civilian sector. OPs exposure inhibits enzyme activity, allowing excess acetylcholine to accumulate. Screening of multiple enzymes is highly desirable because it may provide a comprehensive description of the warrior’s capacity fo ...

Rapid identification of asymmetric warfare modes, including unconventional chemical agents based attacks, is vital to the protection of U.S. armed forces personnel. Existing detection methods use bulky and expensive laboratory equipment to analytically determine the identity and concentration of chemical threats, negating their battlefield use. Colorimetric indicators such as the currently deploye ...

This proposal describes a project to develop a pre-concentrator inlet system for a mass spectrometer. The pre-concentrator utilizes a heated mesh design that is coated with a variety of sorbent materials to provide high pre-concentration with adversely affecting the analysis time. An innovative method of evacuating the pre-concentrator chamber provides an additional gain in pre-concentration of 2 ...

DNA microarray technology, in combination with statistical and predictive modeling tools, could be used to evaluate thousands of genes against distinct gene expression patterns induced by chemical/biological agents to provide early identification and speed therapeutic intervention. The overall objective of this Phase II effort is to leverage existing public domain resources and commercial tools t ...

Many believe the greatest threat to our troops and homeland security are attacks using biological weapons. Recent developments of biological warfare agents parallel advances in microbiology, viruses and bacteria can be rendered more lethal through genetic engineering, and many toxins can be mass-produced. However, detecting biological agents is difficult and time consuming because there are thousa ...

Manning Applied Technology proposes to develop a handheld infrared spectrometer, ideally suited to detection of airborne chemical agents at and below permissible exposure limits. This approach offers unmatched sensitivity and specificity for detection of all types of chemical vapors. The instrument is modular, rugged, compact and highly sensitive. Volume pricing will be less than $1000 each. ...

Effective collective protection fabrics must have a reliable closure system. During our Phase I Work Plan, Sigma-K began developing a Hermetic Textile Closure Hardware (HATCH) system. The HATCH combines both a magnetic and geometric self locking mechanism that will provide a hermetic seal when closed. Our current Phase I successes include developing self closing samples that can provide a hermetic ...

DNA microarray technology, in combination with statistical and predictive modeling tools, could be used to evaluate thousands of genes against distinct gene expression patterns induced by chemical/biological agents to provide early identification and speed therapeutic intervention. The overall objective of this proposal is to demonstrate the feasibility of building a data management system for DN ...

In the wake of the September 11th attacks and subsequent Anthrax scares, researchers worldwide are working to expand our ability to rapidly assess what poses a terrorism threat to the public. The rapid detection of specific pathogens is required for biod

During the anthrax attacks in 2001, investigators had difficulty in differentiating the strains apart because B. anthracis has a low level of genetic variability. This event demonstrated the need for rapid and precise molecular subtyping technologies. Lynntech proposes to develop an ultra-sensitive quantum dots-based molecular beacon fluorogenic reporter system to identify the presence of specif ...