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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Rapid Point-of-Care Tests to Simultaneously Quantify Anti-TB Drugs in Blood

    SBC: ZYMERON CORP            Topic: NIAID

    TuberculosisTBis currently the leading infectious cause of death worldwideTB treatment includes multiple different combinations of antibioticsdosesand long time periodsThe current standard includes an intensive phase ofmonthsfollowed by a continuation phase of eitherormonthsHowevertreatment outcome can be poor due to drug drug interactionsimpaired medication adherencedrug absorption and metabolism ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. In Vivo Targeted Degradation of HIV Gag Polyprotein by Gag-PROTAC Reagents

    SBC: ZYMERON CORP            Topic: NIAID

    HIV disease continues to be a serious health issue for the whole worldCurrentlyantiretroviral therapyARTis a widely accepted treatment to HIV infected patientswhich reduces morbidity and mortality and the potential for HIV transmission by suppressing viral replicationHowevertreatment outcomes of ART are limited due to the high adherence requirement and occurrence of drug resistanceProteolysis targ ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Rapid Point-of-Care Diagnostics to Detect Serologic Status of Individuals for Select Viral Infections

    SBC: ZYMERON CORP            Topic: NIAID

    CytomegalovirusCMVis a very common intrauterine infectionaffecting approximately one in everychildrenThe overall disease burden in the US with congenital CMV was estimated at $billion annuallyCMV is also a cause of serious morbidity and fatal infections in immunocompromised patientsThere is currently no generally accepted therapy and developing a CMV vaccine is high priorityCurrently CMV trials re ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Development of Nanvas TM (Oil in Water Nanoemulsion Adjuvant) Formulated Allergens as Intranasal Immunotherapeutic Vaccines for Peanut Allergy

    SBC: BLUEWILLOW BIOLOGICS INC            Topic: NIAID

    Food allergy is an emerging health problem with increasing incidence and severityparticularly in childrenand continuing throughout adulthoodSincethe incidence of self reported peanut allergy has risen significantly representing a mounting financial burden to the healthcare systemWith no approved therapeutics availablevarious forms of immunotherapy have been evaluated but generally do not facilitat ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. SBIR PHASE II TOPIC 294:SITE-SPECIFIC ANTIBODIES FOR GLCNACYLATED PROTEINS IN CANCER; HHSN261201300058C; POP: 9/13/13-09/12/16; CAN: 8478363 IGF::OT::IGF OTHER FUNCTIONS

    SBC: DETROIT R & D, INC.            Topic: NCI

    O GlcNAcylation of proteins plays a critical role in cell cycle regulationapoptosis and signal transductionModification of O GlcNAcylation of proteins by O GlcNAc transferase is reversible by the activity of O GlcNAcaseAddition and removal of O GlcNAc moiety to serine or threonine regulate the function of proteins directly or via decreased phosphorylationO GlcNAcylation of c myc proteins induces u ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  6. SBIR PHASE 1- TOPIC 394- COMBINATORY TREATMENT MODALITIES UTILIZING RADIATION TO LOCALLY ACTIVATE OR RELEASE SYSTEMICALLY DELIVERED THERAPEUTICS.

    SBC: ZYMERON CORP            Topic: NCI

    Photodynamic therapyPDTutilizes light beam to activate photosensitizers to produce cytotoxic reactive oxygen speciesROSand it has been proposed as a potent treatment to combine with Radiation TherapyRTespecially for the idea of using X ray beam to locally activate PDTXPDTMajority studies about XPDT have used nanoscintillators as the X ray transducer to activate photosensitizersHoweverthe materials ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. TOPIC 382- INTEGRATED IMAGING AND MOLECULAR ANALYSIS OF GLIOBLASTOMA USING SCOPE SEQ ON THE AIR FLOW

    SBC: CELL MICROSYSTEMS INC            Topic: NCI

    Combining both genomic analysis and highEresolution imaging on a cellEbyEcell basis typically relies on customized technology which often requires significant expertise and capital costCell MicrosystemsInchas partnered with Peter SimsPhD of Columbia University to commercialize a novel workflow for integrated imaging and sample preparation for single cell transcriptomic analysisDrSims workflowSingl ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Development and evaluation of an all-in-one integrated webbased buprenorphine treatment program for opioid use disorder (Digital Interventions for Opioid Disorders- DIOD)

    SBC: WORKIT HEALTH INC            Topic: NIDA

    Workit Health will develop an automated system that helps clinicians organize and analyze patient dataPatients will express higher rates of treatment adherence in Medication Assisted Treatment in conjunction with psychosocial supportWorkit Health will conduct a randomized clinical trial that combines psychosocial support through CBT modules and peercounselor support and the DIOD program which adds ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. An integrated device and system for drug detection and deactivation to deter controlled substance theft in hospitals and other healthcare delivery settings.

    SBC: CERTIRX CORPORATION            Topic: NIDA

    Under the Small Business Innovation Research ProgramSBIRPhase I programTopicthe Contractor will develop an integrated device and system for drug detection and deactivation to deter controlled substance theft in hospitals and other healthcare delivery settings

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Development of a fixed-dose combination therapy for the treatment of chronic musculoskeletal pain

    SBC: NeuroCycle Therapeutics, Inc.            Topic: NIAMS

    PROJECT SUMMARY Non steroidal anti inflammatory drugsNSAIDsare a first line pharmacologic pain therapy for chronic musculoskeletal painand rheumatoid arthritisRAand moderate to severe osteoarthritisOAspecificallyHoweverinsufficient pain relief by NSAID monotherapy has encouraged the use of combination therapyCombinations of NSAIDs plus weak opioids are widely used although objective evidence for e ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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