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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Biphase Extended Release Tablet Formulation for Nerve Agent Pretreatment

    SBC: ZYMERON CORP            Topic: CBD181004

    Nerve agents exert their toxic effect by binding to and inactivating enzyme acetylcholinesterase, a key enzymatic regulator of cholinergic neurotransmission. The binding becomes irreversible after a varying amount of time with nerve agents and this aging process limits the treatment window of oxime reactivators. To enhance the current antidote treatment of nerve agent autoinjectors, a pyridostigmi ...

    SBIR Phase I 2019 Department of DefenseOffice for Chemical and Biological Defense
  2. Dual Formulation of Atropine/Scopolamine with Enhanced Stability

    SBC: CMC PHARMACEUTICALS INC            Topic: CBD181005

    CMC Pharmaceuticals, Inc. (Cleveland, OH) is proposing developing a stable, combination product of two small molecule drug candidates as a counter measure to chemical warfare nerve agents (NA). The combination product is expected to exploit complementary pharmacological profiles for optimal muscarinic receptor blockade and anticholinergic activity within the peripheral and central nervous system. ...

    SBIR Phase I 2019 Department of DefenseOffice for Chemical and Biological Defense
  3. Field Portable Mass Spectrometry for Small Molecule Drugs in Clinical Samples

    SBC: SPECTRAL ENERGIES LLC            Topic: CBD181006

    We propose a novel two-dimensional mass spectrometry (2D-MS) technique based on ion trap arrays to identify illicit and designer drugs. This approach will give an unprecedented multiplex advantage for miniature mass spectrometry, allowing novice field technicians to rapidly identify drugs affecting the central nervous system based on both the m/z ratio and fragmentation pattern of an ion. Towards ...

    SBIR Phase I 2019 Department of DefenseOffice for Chemical and Biological Defense
  4. Bi-specific Antibodies Targeting Disease Caused by Encephalitic Alphaviruses

    SBC: BRHMS LLC            Topic: CBD181007

    Highly pathogenic alphaviruses like VEEV/EEV/WWEEV cause encephalitis in humans and equids. These infections are endemic in wide regions of the developing world. Translational research regarding these pathogens is focused on developing new strategies to detect, treat and ideally protect humans and animals from these infections. Gene-encoded antibodies against alphavirus E1/E2 surface proteins will ...

    SBIR Phase I 2019 Department of DefenseOffice for Chemical and Biological Defense
  5. MicroLens Hyperspectral Imager for Standoff Chemical Detection

    SBC: NANOHMICS INC            Topic: CBD171002

    For standoff chemical identification applications, the longwave infrared has several key lines for spectral discrimination. Unfortunately, most hyperspectral systems are quite large and fragile, making them unwieldy. Nanohmics proposes to demonstrate a chip-scale longwave infrared hyperspectral imaging technology. The weight and packaging volume will be dominated by the fore-optics instead of the ...

    SBIR Phase II 2019 Department of DefenseOffice for Chemical and Biological Defense
  6. Analysis Tools for Detection and Diagnosis of Biological Threats

    SBC: ALPHA-GAMMA TECHNOLOGIES, INC.            Topic: CBD04113

    DNA microarray technology, in combination with statistical and predictive modeling tools, could be used to evaluate thousands of genes against distinct gene expression patterns induced by chemical/biological agents to provide early identification and speed therapeutic intervention. The overall objective of this Phase II effort is to leverage existing public domain resources and commercial tools t ...

    SBIR Phase II 2005 Department of DefenseOffice for Chemical and Biological Defense
  7. Portable System for Sample Preparation and Differentiation of Pathogens at Strain Level

    SBC: LYNNTECH INC.            Topic: CBD04107

    Many believe the greatest threat to our troops and homeland security are attacks using biological weapons. Recent developments of biological warfare agents parallel advances in microbiology, viruses and bacteria can be rendered more lethal through genetic engineering, and many toxins can be mass-produced. However, detecting biological agents is difficult and time consuming because there are thousa ...

    SBIR Phase II 2005 Department of DefenseOffice for Chemical and Biological Defense
  8. Handheld Photoacoustic Chemical Agent and Toxic Industrial Material Detector

    SBC: MANNING APPLIED TECHNOLOGY            Topic: CBD05112

    Manning Applied Technology proposes to develop a handheld infrared spectrometer, ideally suited to detection of airborne chemical agents at and below permissible exposure limits. This approach offers unmatched sensitivity and specificity for detection of all types of chemical vapors. The instrument is modular, rugged, compact and highly sensitive. Volume pricing will be less than $1000 each. ...

    SBIR Phase I 2005 Department of DefenseOffice for Chemical and Biological Defense
  9. Decontamination of Biological Warfare (BW) Agents, Toxic Industrial Chemicals (TICs) and Toxic Industrial Materials (TIMs)

    SBC: MATERIALS ENGINEERING AND TECHNICAL SUPPORT SERVICES CORP.            Topic: CBD05113

    The US Government has spent hundreds of millions of dollars developing decontamination capabilities to protect our military personnel and equipment from chemical warfare agents. With much of the traditional research and development efforts within focused on decontamination of chemical warfare (CW) agents, there has been a recent shift in the research base to include biological warfare (BW) agents ...

    SBIR Phase I 2005 Department of DefenseOffice for Chemical and Biological Defense
  10. Reducing the Weight and Volume of Peroxide-Based Decontaminant by using a Solid (Vice Liquid) Component for Hydrogen Peroxide

    SBC: MATERIALS ENGINEERING AND TECHNICAL SUPPORT SERVICES CORP.            Topic: CBD05114

    Several new generation chemical and biological (CB) decontaminants are based on hydrogen peroxide (H2O2) chemistry. These new decontaminants have many desirable characteristics, including reactivity toward a broad spectrum of CB agents and toxins, as well as being less corrosive and more environmentally friendly than conventional decontaminating materials. However, these systems are still liquid b ...

    SBIR Phase I 2005 Department of DefenseOffice for Chemical and Biological Defense
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