Award Data

In Phase I, Aerius Photonics demonstrated Raman spectroscopy at 785 nm, 980 nm, and 1064 nm, with only 1064 nm-based excitation showing a reduction in fluorescence. In addition, Aerius Photonics and partner Ahura Scientific, demonstrated a breadboard version of an InGaAs-based Raman spectrometer to assess any engineering challenges. By the end of a Phase III, Aerius proposes to develop a handheld ...

Organophosphorus chemical warfare nerve agents (OP-CWA) are attractive to terrorist groups and rogue states as an inexpensive and accessible technology for chemical warfare. OP-CWA and organophosphate pesticides cause severe neurological symptoms and death by inhibiting the enzyme acetylcholinesterase (AChE); the resulting excess acetylcholine accumulates and overstimulates the human or animal bo ...

DESCRIPTION (provided by applicant): This project will focus on the development, implementation and evaluation of messaging designed to increase the availability and selection of healthier restaurant dining choices and positively impact public health. During Phase I, communication specialists will assist in developing effective messages that will (1) attract restaurants to provide and promote heal ...

Currently fielded respiratory protective systems in the Joint Services General Purpose Mask (JSGPM) program degrade in visual performance capability in extreme hot and cold environments. Optical and mechanical properties of existing anti-fog coatings also diminish when subjected to cleaning/sanitization operations. To address these needs, InnoSense LLC (ISL), in Phase I, has combined nanomaterials ...

Building on our successful Phase I work our Phase II objectives are to complete development and integration of our two proposed sensors into an unprecedented self-confirming MeS detection system further refining our ability to meet key requirements identified in Phase I. More specifically, we will develop a NEMS based MeS sensor system complete with a telemetry system and/or a remote logging, data ...

DESCRIPTION (provided by applicant): The objectives of the Phase II research are to develop a simple and cost-effective method for large-scale production of anti-microbial N95 respirator masks. The work proposed will accomplish the necessary steps to scale our production of a Light Activated Anti Microbial (LAAM) fabric coating to manufacturing. Significance: Influenza and other enveloped viruses ...

To address the CBD need for improved formulations to enhance the ease of use and bioavailability of antisense therapeutics, Physical Optics Corporation (POC) proposes to develop a Multifunctional Antisense Therapeutics Nanocarrier and Inhalation Device (MATEN). This proposed system is based on a new dry powder formulation and a novel design of an inhaler that uses in-house developed mature compone ...

Impregnated ASZM-TEDA carbon employed as highly adsorptive materials in Collective Protection (ColPro) systems loses the ability to adsorb toxic chemicals because of exposure to temperature, humidity, battlefield contaminants, and other pollutants. To address the Chemical and Biological Defense (CBD) need for a residual life indicator (RLI) capable of probing the degradation in physical adsorption ...

To address the Chemical/Bio Defense (CBD) need for in vitro models suitable for high-throughput screening of drug toxicities in human tissues, Physical Optics Corporation (POC) proposes to develop a new three-dimensional (3D) Microfluidic Platform for in-vitro Hematopoietic Stem Cell (HSC) Culture (3D-Mic-Stem). This proposed system is based on a 3D microfluidic design that uses HSCs for assaying ...

To address the U.S. Army/DTRA’s CBD program need for a robust screening process for use with large panels of enzymes to identify variants with higher affinity for organophosphorus (OP) substrates, Physical Optics Corporation (POC) proposes to develop a Microfluidic Dielectrophoretic Screening (MDS) system. This proposed system is based on the new design of a microfluidic mixer, enzymatic reactor ...