Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until September, 2020.

  1. PLATFORM FOR NEUROCOGNITIVE EVALUATION AND MONITORING

    SBC: ENFORMIA INC.            Topic: NCI

    Current standardized neuropsychological tests are based on decades old paper and pencil methods They lack reliability sensitivity specificity repeatability and require trained neuropsychologists to administer them Their administration in clinical and research settings result in high cost complexity and inconsistent results There is a need and a commercial opportunity for an extensible co ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. An RNA targeted platform for anti flavivirus drug discovery

    SBC: Ribometrix LLC            Topic: NIAID

    SUMMARY Emerging and re emerging mosquito borne flaviviruses cause widespread mortality morbidity and economic burden Options for prevention and treatment of mosquito borne flaviviruses are limited Flavivirus vaccines face unique development challenges no antiviral therapies are available and the mosquito vectors have proven difficult to eradicate Despite vaccines against Yellow Fever and J ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Peptide based tool for the rapid isolation of quiescent monocytes from peripheral blood

    SBC: AFFINERGY, LLC            Topic: 102

    SUMMARY ABSTRACT Dendritic cell DC therapy represents a new and promising immunotherapeutic approach for treatment of advanced stage cancers with DC vaccines already approved for use in advanced prostate cancer and more than DC based vaccines in the clinical development pipeline for other cancers In particular the US market for cancer vaccines including DC based vaccines is set to expan ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Novel injectable resiquimod formulation for treatment of metastatic cancers

    SBC: Curebiotech, Inc.            Topic: NCI

    PROJECT SUMMARY Malignant melanoma is one of the most aggressive types of skin cancer causing a large majority of skin cancer related deaths worldwide Recently there have been staggering breakthroughs with the advent of drugs that act on checkpoint inhibitors These are paradigm shifting immunotherapeutic agents not only for melanoma but for cancers in general because they harness the bodyan ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. CRISPR Cas Systems Delivered by Targeted Nanoparticles to Eradicate Herpesvirus Pathogens

    SBC: Theragnostic Technologies Inc.            Topic: NIAID

    Abstract Herpesviruses are chronic pathogens that infect for life there is no cure years since the discovery of the first tumor virus the herpesvirus Epstein Barr virus EBV there exist no specific antivirals for EBV during its latency phase and there are no vaccines The same holds true for most of the other eight human herpesviruses This proposal aims to develop novel tools to eradicat ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. A Nitric Oxide Polymer Platform for the Prevention and Treatment of Infected Wounds

    SBC: IFYBER, LLC            Topic: NIAID

    This proposed SBIR research effort will lay the foundation for commercializing a new class of biomaterial for the prevention and treatment of infected skin wounds thereby enhancing patient health through improved patient outcome and reduced patient morbidity Specifically we will focus on evaluating and developing a biomaterial comprised of a nitric oxide NO releasing based on a commonly used ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Microfluidic S nitrosothiol Sensor

    SBC: CLINICAL SENSORS, INC.            Topic: 400

    PROJECT SUMMARY This Small Business Innovation Research SBIR Phase I project aims to develop an accurate rapid and commercially available microfluidic sensor that measures low molecular weight S nitrosothiols in biological samples S nitrosothiols RSNOs the primary transporters of nitric oxide NO in physiology play a critical role for NOandapos s bioactivity Homeostatic control of low ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. High throughput screening of arrayed single cells for automated analysis of phenotypic heterogeneity

    SBC: Celldom, Inc.            Topic: 300

    ABSTRACT The overall objective of this SBIR Phase I proposal is to develop a high throughput screening platform that can analyze the phenotypic heterogeneity of single cells exposed to small molecule growth inhibitors To achieve this objective we will conduct the following specific aims demonstrate a commercially viable approach for rapidly organizing andgt single cells into an arra ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Fluorescent reporters for real time single cell Pol III transcription measurement

    SBC: Lucerna Inc.            Topic: 400

    SUMMARY RNA polymerase III Pol III is increasingly recognized as an important drug target and a rapidly developing area of academic research Pol III is responsible for generating RNAs that are critical for cell growth such as tRNAs certain rRNAs and various noncoding RNAs involved in processes such as mRNA splicing These RNAs are required for cell growth proliferation and differentiation ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Centralized assay datasets for modelling support of small drug discovery organizations

    SBC: COLLABORATIONS PHARMACEUTICALS, INC.            Topic: 400

    Summary The objective of Assay Central is to compile a comprehensive collection of datasets for structure activity data for a broad variety of disease targets and absorption distribution metabolism excretion and toxicology ADMET properties in a form that is immediately ready for model building and other forms of analysis using cheminformatics methods This is aided by the existence of many ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
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