Award Data

This SBIR Phase II project aims to create and test a game-based intelligent tutoring system that both assesses and improves the behavioral readiness and social emotional skills of Kindergarten and 1st grade students. Research has shown that early intervention for children with social skill deficiencies is critical for success in the classroom and success in life. Children from vulnerable, underser ...

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase II project will be the redefinition of the care of asthma patients. Asthma is highly prevalent in the US, with 25 million patients currently suffering symptoms, and was the cause of 1.7 million emergency room visits in 2015, resulting in a huge societal cost. A predictive platform that can identify when ...

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase II project will be to help usher in personalized and tailored surgical care within a shifting healthcare context toward value-based care. Hospitals and surgeons are seeking solutions that will enable them to target, as opposed to generalizing, improvements in surgical quality for enhanced patient outcom ...

After the Daiichi nuclear disaster, the US Congress placed emphasis on accident tolerant fuels for reactors.During accident events, voids in cooling fluid can cause cladding weakening, and it is important to measure these effects in a controlled test.The project develops a fast void detector that can detect and localize voids, with a quantifiable detection limit superior to a capacitive void senso ...

Abstract Significance: Donor tissue shortage remains a critical problem in lung transplantation. Recent advances in tissue engineering have allowed for the possibility of generating bioengineered lungs from decellularized organ scaffolds. These scaffolds, created from the donor’s tissue, become functionalized after recellularization with a patient’s own cells. However, translation of whole-lun ...

Project SummaryGenome editing technologies, such as CRISPR/Cas9 provide a rapid, and targeted means of both knocking out gene expression and knocking in gene modifications. Since our initial Phase I submission, the utility of CRISPR technology has expanded beyond the generation of cell lines, to forward genetic screening, in vivo manipulation of gene expression and even human therapeutics. Phase I ...

PROJECT SUMMARY Glioblastoma (GBM) is an intractable cancer with an average survival time of 12 to 15 months. Treatment options are limited by the infiltration of tumor cells into healthy tissue and the difficulty of delivering effective chemotherapeutics across the blood brain barrier, but engineered neural stem cells (NSCs) hold great promise as GBM therapies because they selectively migrate to ...

The goal of this project is to develop novel technology for predicting drug-induced kidney injury such as caused by systemic antimicrobials, diuretics, anticancer agents, and anti-inflammatory drugs. Drugs cause approximately 20 percent of community- and hospital- acquired episodes of acute renal failure, but the incidence in older adults may be as high as 60 percent. A significant problem is that ...

Low molecular weight heparins (LMWHs) are partially depolymerized natural products of heparin, which are isolated from porcine intestine. A worldwide distribution of contaminated heparin in 2007 was associated with 85 deaths in the US. This crisis revealed the vulnerability of the LMWH supply chain. LMWHs are complex mixtures, having average molecular masses of 3500-6000 Daltons, corresponding to ...

The objective of this research is to create a clinical prototype of a new optical coherence tomography (OCT) system suitable for diagnostic retinal imaging at the point of care. The target system price will be one third the price of currently available research OCT systems while providing performance comparable to other entry level OCT imaging systems. By breaking the $15,000 system barrier we wil ...