Award Data

To address U.S. Navy needs, Sentient proposes to establish a Design Framework for reliability assurance of additive manufactured (AM) parts using their DigitalCloneTM Component (DCC) software. The framework will be tailored to metal components built through AM processes with complex geometries. Sensors are embedded during AM component build to allow for exploitation of sensor data, physics-based m ...

In the near future unmanned aircraft systems (UAS) will be utilized for many societal and commercial applications. However, the hurdle of operation safety in the form of avoiding airborne collisions must first be overcome. UAVradars LLC is proposing a small, lightweight, and low-power radar system designed specifically to give small UAS (< 55 lbs) airborne collision-avoidance sensory capability. ...

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase II project is the development and scale-up of a manufacturing platform for producing bio-based chemicals for application in lubricants. This manufacturing platform will utilize biologically derived sugar carbon-source and transform this carbon to higher value products via microbial fermentation. In cont ...

Idaho Scientific proposes to design and develop, SPUD, an irrefutable tamper logging protocol.During the course of this Phase I effort, Idaho Scientific will implement the core of the logging protocol and develop a set of unit tests designed to evaluate properties of that protocol that uphold its irrefutable claims. During a Phase II effort, Idaho Scientific would propose to encapsulate this proto ...

Advanced Ceramic Fibers, LLC (ACF) completed the Navy SBIR Phase I Base Program and clearly demonstrated the feasibility of our approach to create a truly robust composite for turbine engines that exceeds the known boundaries for ceramic composites and the Navy performance objectives for this Topic. Our engineered materials approach involved in-depth background experience in ceramic matrix composi ...

DESCRIPTION provided by applicant The objective of this Phase I STTR research is to develop and test osteoinductive lumbar spinal fusion implant prototypes made using materials technology developments discovered by the PI at the University of Kansas In preliminary work lower impedance piezoelectric composite materials that generate power for direct current DC electrical stimulation applica ...

DESCRIPTION provided by applicant The drug development pipeline is plagued by unacceptable rates of attrition due in large part to toxicities that are not identified in pre clincal stages of development The ability to de risk lead compounds during pre clinical development with advanced andquot organoid on a chipandquot technologies show tremendous promise Chemotherapeutics in particular whi ...

DESCRIPTION provided by applicant Melanoma the fastest growing cancer incidence in the world today and the American Cancer Society reports that death rates for melanoma continue to rise Alarmingly melanoma is the most common cancer in young adults under One characteristic of metastatic melanoma cells that is recognized as a potential target for new therapies is upregulation of cell surfac ...

DESCRIPTION provided by applicant The primary goal of this Phase I pediatric oncology clinical trial will be to evaluate the safety and use of demethyl cholesteryloxycarbonylpenclomedine DM CHOC PEN as anticancer therapy for children with advanced cancer involving the central nervous system CNS DM CHOC PEN is a polychlorinated pyridine cholesteryloxycarbonate that crosses the blood br ...

DESCRIPTION provided by applicant Skeletal muscle atrophy is a highly prevalent condition caused by advanced age muscle disuse chronic illness critical illness and malnutrition In addition to being very common muscle atrophy has serious consequences including weakness reduced activity and quality of life falls fractures extended hospitalizatio and rehabilitation nursing home placem ...