Award Data

PROJECT SUMMARY Although the ubiquity of metabolic problems in pulmonary hypertension (PH) has been known for more than a decade, a wealth of new details on the nature of this problem presents the opportunity for intervention. A combination of experimental work in cells and animals and early trials in humans, suggests that these metabolic problems are part of the causation for PH, and that inactiv ...

SPECIFIC AIMSApproximately 90% of lung cancer results from smoking. Low Dose Computerized Tomography (LDCT) of smokers can detect lung cancer earlier allowing more effective treatment. But determining which smokers should get LDCT screening is controversial and potentially harmful. Recently, the U.S Preventive Services Task Force (USPSTF) updated their opinion on screening to recommend annual LDCT ...

Project Summary/Abstract: The U.S. has more health science STEM jobs available than qualified workers to fill them and lags other OECD nations in math and science, with major achievement gaps and STEM workforce under-representation among women and students of color. Improved STEM education is needed in high school and early collegiate settings that engages, prepares, and inspires all students—an ...

Development and feasibility demonstration of a prototype rapid and accurate Lateral Flow Assay (LFA) to self-screen qualitatively for exposure to Hepatitis C Virus (HCV) in at-home settings, is proposed. The LFA, employing conserved immunogenic domains of proteins comprising the HCV human immunoproteome, will detect host antibody responses to such immunogenic protein domains in user-generated fing ...

Genetically Engineered Mice for Pre-clinical Evaluation of HIV Vaccine Candidates: The development of novel HIV candidate vaccines generally requires preclinical testing in animal models before proceeding to Phase I clinical trials. Multiple efforts have focused on developing and evaluating innovative platforms and formulations of HIV envelope (Env) immunogens for the induction and generation of a ...

SIGNIFICANCE: Neuroblastoma is the most common pediatric cancer, accounting for 15% of cancer deaths, with a 5-yr survival of lt40% due to resistant metastases. Neuroblastoma tumors almost universally express the somatostatin receptor 2 (SSTR2) and high expression has been shown clinically using peptides targeting SSTR2 (PMID10706954). FDA approved SSTR2-targeted beta(β-)-emitting 177Lu-labeled L ...

Project Summary. The COVID-19 pandemic has magnified the need for enhanced ability to accurately anticipate future outbreaks due to novel and endemic viral pathogens. Without systematic surveillance, the ability to head off outbreaks before they occur is challenging: the data from positive human test results is often too late to prevent a major outbreak from occurring, despite substantial lockdown ...

Revised. Metastatic melanoma is a lethal disease because low response rates (near 50%), acquired resistance, and severe adverse side effects limit long-term quality of life for these patients (5-yr. survival lt30%). Radiopharmaceutical therapies are emerging as an exciting alternative in oncology and systemic receptor- targeted alpha-particle therapy (a-RT) is emerging as particularly transformati ...

ABSTRACT Outcomes in pediatric liver transplantation (pLT) are not limited by the donated organ supply. Kids are dying waiting for organs even when these deaths are completely preventable through proper organ selection. Instead of dying, children can live a full and active lifetime with a properly selected liver graft for transplant. Critical to achieving zero waitlist mortality and long-term tran ...

Gene-diet interactions can have major effects on human development, aging and response to medical therapy. In particular, this is true for key nutrients such as Vitamin A, D, B9 and B12. Unfortunately, the current “one size fits all” approaches for determining whether an individual has adequate levels of these and other micronutrients relies on older studies that use serum assays that only cap ...