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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Classification of Breast Lesions In Ultrasound Imaging

    SBC: Advanced Applications            Topic: N/A

    We will develop a computer-assisted system to improve the ability of breast sonography to distinguifrom benign lesions. These are lesions originally detected by mammography and sent to ultrasound forThe lesions are biopsied when they are classified by ultrasound as solid or indeterminate, even thoubenign at biopsy. Because of the large numbers of breast biopsies being performed, even a small impro ...

    SBIR Phase I 1995 Department of Health and Human Services
  2. Mouse Chromosome-Specific Painting Probes

    SBC: APPLIED GENETICS LABORATORIES            Topic: N/A

    We have described a new technology called "preparative in situ hybridization (Prep-I.S.H.), which is capable of isolating a set of cDNA or genomic clones according to their chromosome location. The technology takes advantage of in situ hybridization of cloned DNAs to metaphase chromosome spreads, chromosome microdissection, and the polymerase chain reaction (PCR). We will use this technology to de ...

    SBIR Phase II 1995 Department of Health and Human Services
  3. Polymorphic Markers for Chromosome Band 11e2

    SBC: APPLIED GENETICS LABORATORIES            Topic: N/A

    Our research decribes a strategy for producing a high density set of PCR-base microsatellite markerpolymorphic in L5178Y, the cell line used in the mouse lymphoma assay (MLA). These polymorphic marketwo detailed long range restriction maps in the vicinity of the thymidine kinase (tk-1) gene, with tdefined distances from each other and the tk-1 gene. The first, lower resolution map will define thet ...

    SBIR Phase I 1995 Department of Health and Human Services
  4. Geneid--A New Gene Mapping and Finding System

    SBC: APPLIED GENETICS LABORATORIES            Topic: N/A

    This proposal describes a set of reagents which will make gene mapping to chromosomes and chromosomas well as gene finding exercises, accessible to any molecular biologist or geneticist familiar withtechniques. These reagents, called the Gene. ID system, are a set of "dot-blots". The "Chromosome.IDcorresponding to each chromosome spotted in a dot-blot format and the "Band.ID" blot contains DNA coe ...

    SBIR Phase I 1995 Department of Health and Human Services
  5. Provide Sequence Analysis of TK and HPRT Gene Mutations

    SBC: APPLIED GENETICS LABORATORIES            Topic: N/A

    We propose using new molecular techniques to survey the spectrum of mutagenic events occurring at tL5178Y cells. We will compare this spectrum with the range of abnormalities occurring in human cancemouse lymphoma assy (MLA) as an accurate reflection of events of human significance. Specifically,mutants will be screened for tk-l allele loss by Southern blotting. Small lesions will be analyzed bse ...

    SBIR Phase II 1995 Department of Health and Human Services
  6. Preparation of Mouse Chromosome Painting Kits

    SBC: APPLIED GENETICS LABORATORIES            Topic: N/A

    N/A

    SBIR Phase I 1995 Department of Health and Human Services
  7. Shac--Isolation of Chromosome Region Specific CDNA

    SBC: APPLIED GENETICS LABORATORIES            Topic: N/A

    N/A

    SBIR Phase I 1995 Department of Health and Human Services
  8. Quadrature RF Coil Arrays for MRI of the Human Breast

    SBC: Applied Resonance Technology            Topic: N/A

    The long range objective is to develop a radio frequency (RF) antenna array for optimized magnetic resonance imaging (MRI) of the human breast. Recent MRI technique development has made possible sensitive detection of breast cancer and other abnormalities, but the major manufacturers of MRI systems have not provided high performance RF coils; the coils would help make these techniques practical fo ...

    SBIR Phase II 1995 Department of Health and Human Services
  9. Instrumentation & Reagents for Ion/2nd Messenger Imaging

    SBC: Atto Instruments, Inc.            Topic: N/A

    In this grant, we seek to fully implement one aspect of our overall long term goal of developingadvanced instrumentation and reagents for ion and second messenger imaging and analysis. Ourinstrumentation development efforts have-proceeded quite well in the area of hardware and softwareto support any combination of dual excitation and or dual emission fluorescent ratio imaging. We willapply our uni ...

    SBIR Phase II 1995 Department of Health and Human Services
  10. SSI Awareness ans Access

    SBC: Benton & Associates            Topic: N/A

    This project identifies the state and local child welfare agencies that are doing the best job in securing access to SSI on behalf of children in substitute care, 2) documents the Best Practices of those jurisdictions, 3) pretests a screening tool, 4) develops a Training and Technical Assistance Package, and 5) develops a marketing strategy for making the screening tool available to state and loca ...

    SBIR Phase II 1995 Department of Health and Human Services

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