Award Data

PHASE I TESTS THE FEASIBILITY OF COMBINING SEVERAL TELEPHONE TECHNOLOGIES IN NEW WAYS USING A MULTIMEDIA APPROACH TO PRESENT CANCER PREVENTION/HEALTH PROMOTION TO ADULTS FROM DIVERSE BACKGROUNDS. TECHNICAL INNOVATION COMES FROM APPLYING THESE TECHNOLOGIES, E.G. VOICE PROCESSING, FAX-STORE-AND-FORWARD, AND TDD (TELECOMMUNATIONS DEVICES FOR THE DEAF), TO FUNCTION IN A SEAMLESS, COHERENT MANNER. OUTC ...

THE DETECTION OF AUTOANTIBODIES IN THE LIVER DISEASES PBC, PSC AND CAH MAY SERVE AS A DIAGNOSTIC IN ASSESSING THE SEVERITY AND/OR PROGRESSION OF DISEASE. IN PHASE I WE PLAN TO DEVELOP ENZYME-BASED IMMUNOASSAYS (EIAS) FOR THE DETECTION OF AUTOANTIBODIES ASSOCIATED WITH PBC. WE PLAN TO USE THE RECOMBINANTLY ENGINEERED MOLECULE "PDC-E2/BCOADH-E2" WHICH CONTAINS THE ANTIGENIC DETERMINANATS FOR THE TWO ...

N/A

THE LONG-TERM OBJECTIVE OF THIS RESEARCH IS TO DESIGN, BUILD AND COMMERCIALIZE A MEDICAL IMAGING SYSTEM BASED ON ELECTRICAL IMPEDANCE TOMOGRAPHY (EIT). EIT IS AN ATTRACTIVE DIAGNOSTIC TOOL DUE IN PART TO ITS LOW-COST BUT MORE SO BECAUSE IT DIFFERENTIATES TISSUE ACCORDING TO ITS ELECTROCHEMICAL PROPERTIES AS OPPOSED, SAY TISSUE DENSITY ALONE. IN THE PAST, THE DIFFICULTY WITH EIT HAS BEEN IN OBTAINI ...

WE PLAN TO MAKE A FLUORESCENT MARKER FOR NEOVASCULARIZATION. SEPCIFICALLY, WE WANT TO STAIN NEW BLOOD VESSELS WITH FLUORESCENT ANALOGUE OF FLUORESCEIN. THIS WOULD BE USEFUL IN ASSESSING DIABETIC RETINAL CHANGES AND ALSO IN LIMITED SUBSETS OF AGE RELATED MACULAR DEGERNATION. WE HAVE FOUND A SPECIFIC MARKER FOR NEOVASCULARIZATION, BEING UPA. WE WILL THEN FIND AND DEVELOP A FLUORESCEIN COMPOUND, SPEC ...

BLEEDING INTO THE ANTERIOR OR VITREAL CHAMBERS OF THE EYE MAY RESULT FROM BLUNT TRAUMA OR AS A COMPLICATION OF VITRECTOMY. TRAUMATIC HYPHEMA IS HEMORRHAGE INTO THE ANTERIOR CHAMBER OFTEN RESULTING FROM BLUNT TRAUMA. HYPHEMAS MAY LEAD TO CORNEAL BLOOD STAINING, SECONDARY GLAUCOMA, CHRONIC OPEN ANGLE GLAUCOMA, OR CENTRAL RETINAL ARTERY OCCLUSION. THE HEMOSTATIC INHIBITOR OF PLASMINOGEN ACTIVATION EP ...

THE OVERALL OBJECTIVE IS TO DEVELOP A NEW SYRIAN HAMSTER EMBRYO (SHE) MORPHOLOGICAL TRANSFORMATION ASSAY (MTA) EMPLOYING SPECIFIC CELL TYPES AS TARGETS AND USING DEFINED, SERUM-FREE CULTURE MEDIA. SPECIFIC AIMS FOR PHASE I STUDY INCLUDE: (1) ISOLATION AND CHARACTERIZATION OF SPECIFIC CELL TYPES (CHONDROCYTES, MYCOCYTES, FIBROBLASTS, ENDOTHELIAL CELLS) FROM SHE AS TARGETS FOR THE IN VITRO TRANSFORM ...

THE OVERALL OBJECTIVE OF THIS PROJECT IS TO INCLUDE HUMAN PROSTATIC CANCER CELL LINES FOR DISCOVERING CANCER CHEMOTHERPAEUTIC DRUGS. SPECIFIC AIMS OF PHASE I INCLUDE ESTABLISHMENT AND CHARACTERIZATION OF NEW HUMAN PROSTATIC CANCER CELL STRAINS/LINES SUITABLE FOR DRUG EVALUATION. THESE STUDIES WILL INCLUDE THE USE OF SPECIAL CULTURE MEDIA AND EXPERIMENTAL CONDITIONS REQUIRED FOR ESTABLISHMENT OF TH ...

STUDIES WITH NEWLY ISOLATED WILDTYPE MEASLES VIRUSES SUGGEST THAT ANTIGENIC DRIFT MAY BE OCCURRING WHICH COULD ADVERSELY IMPACT THE PROTECTIVE EFFECTS OF CURRENTLY EMPLOYED VACCINES. SUCH AN OCCURRENCE WOULD BE PARTICULARLY DETRIMENTAL TO DEVELOPING COUNTRIES, WHERE ACUTE INFECTION IN YOUNG CHILDREN CAN CAUSE SERIOUS AND FATAL SEQUELAS. IN ORDER TO DETERMINE THE EXTENT AND POENTIAL EFFECTS OF ANTI ...

N/A