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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

  1. THE SURFACE PLASMON IMMUNOASSAY FOR MEASUREMENT OF HCG

    SBC: Adelphi Technology, Inc.            Topic: N/A

    THE SURFACE PLASMON RESONANCE PHENOMENON WILL BE EXPLORED TO DEVELOP A QUANTITATIVE, SENSITIVE, ASSAY SYSTEM FOR REPRODUCTIVE HORMONES OF CLINICAL INTEREST. THE APPROACH CAN ATTAIN, WITH RELATIVELY INEXPENSIVE INSTRUMENTATION, A SENSITIVITY LIMIT COMPARABLE TO EXISTING ASSAY METHODOLOGIES, WITHOUT THE USE OF DYES, RADIOISOTOPES OR ENZYMES FOR SPECIFIC SIGNAL GENERATION. PART OF THE PHASE I RESEARC ...

    SBIR Phase I 1991 Department of Health and Human Services
  2. EARLY PREDICTIVE IMMUNOASSAY FOR PREECLAMPSIA

    SBC: Adeza Biomedical Corpon            Topic: N/A

    WE WILL DEVELOP A NEW DIAGNOSTIC TEST TO SUBSTANTIALLY IMPROVE THE DEFINITIVE DIAGNOSIS OF PE. PE IS A COMMON DISEASE OF PREGNANT WOMEN AFFECTING THE MOTHER, FETUS, AND NEONATE. PE IS CHARACTERIZED BY THE ONSET OF HYPERTENSION, PROTEINURIA AND EDEMA AFTER THE 20TH WEEK OF GESTATION IN PREVIOUSLY NORMOTENSIVE WOMEN. RECENT STUDIES SUGGEST THAT THE PRIMARY PATHOGENESIS OF THIS DISORDER IS UTEROPLACE ...

    SBIR Phase I 1991 Department of Health and Human Services
  3. INORGANIC PLOYMER COATINGS FOR NEURAL PROSTHESES

    SBC: Advanced Diversified Tech Inc            Topic: N/A

    THE CONTRACTOR WILL DETERMINE THE FEASIBILITY OF USING SILICON AND TANTALUM BASED INORGANIC POLYMER COATINGS FOR PASSIVATING NEURAL PROSTHETIC IMPLANTS. THE CONTRACTOR WILL DETERMINE THE FEASIBILITY OF USING SILICON AND TANTALUM BASED INORGANIC POLYMER COATINGS FOR PASSIVATING NEURAL PROSTHETIC IMPLANTS.

    SBIR Phase I 1991 Department of Health and Human Services
  4. AIT-082; A DRUG FOR TREATMENT OF ALZHEIMER'S DISEASE

    SBC: Advanced Immunotherapeutics            Topic: N/A

    N/A

    SBIR Phase I 1991 Department of Health and Human Services
  5. NOVEL X-RAY MAMMOGRAPHY SYSTEM DEVELOPMENT

    SBC: Aracor            Topic: N/A

    WE WILL DEVELOP AND DEMONSTRATE A NEW HARDWARE ARCHITECTURE FOR X-RAY MAMMOGRAPHY SYSTEMS THAT WILL PROVIDE ENHANCED DIAGNOSTIC PERFORMANCE, PRODUCING HIGHER QUALITY IMAGES AT LOWER PATIENT DOSE AND LOWER EXAMINATION COST. THE PROJECT WILL IMPLEMENT A NOVEL LINE-SCAN EXPOSURE METHOD THAT ENHANCES THE SIGNAL-TO-NOISE PERFORMANCE OF THE SYSTEM, IMPROVING ITS SMALL-OBJECT AND DIFFUSE-OBJECT DETECTABI ...

    SBIR Phase I 1991 Department of Health and Human Services
  6. A PHYSIOLOGICAL SKIN REPLACEMENT

    SBC: ADVANCED TISSUE SCIENCES, INC.            Topic: N/A

    A NOVEL PHYSIOLOGIC SKIN MODE HAS BEEN DEVELOPED UTILIZING HUMAN NEONATAL DERMAL FIBROBLASTS CULTURED ON A BIODEGRADABLE, POLYGLYCOLIC OR POLYGLACTIC ACID, MESH. THE PROLIFERATING CELLS STRETCH ACROSS THE MESH OPENING AND SECRETE NATIVE GROWTH FACTORS, COLLAGENS AND OTHER EXTRACELLULAR MATRIX PROTEINS TO PRODUCE AN IN VITRO HUMAN DERMAL TISSUE. HUMAN KERATINOCYTES CAN ALSO BE CULTURED ONTO THIS DE ...

    SBIR Phase I 1991 Department of Health and Human Services
  7. "AN IN VITRO BIOASSAY FOR ESTROGENS AND ANTIESTROGENS

    SBC: Aeron Biotechnology, Inc.            Topic: N/A

    N/A

    SBIR Phase I 1991 Department of Health and Human Services
  8. STUTTERING RECOGNITION USING ARTIFICIAL NEURAL NETWORKS

    SBC: Ai Systems, Inc            Topic: N/A

    WE WILL USE ARTIFICIAL NEURAL NETWORKS TO DEVELOP AN ACOUSTIC-BASED SYSTEM FOR AUTOMATICALLY IDENTIFYING STUTTERING IN CONTINUOUS SPEECH. THE SYSTEM WILL USE THESE NETWORKS, ALREADY DEVELOPED FOR PURPOSES OF SPEECH RECOGNITION, TO IDENTIFY DIFFERENCES BETWEEN PERCEPTUALLY INDISTINGUISHABLE AUTHENTIC AND SIMULATED STUTTERINGS.

    SBIR Phase I 1991 Department of Health and Human Services
  9. HISTOCULTURE OF SKIN FOR TOXICITY ASSAY

    SBC: ANTICANCER, INC.            Topic: N/A

    THERE IS AN IMPORTANT NEED IN THE STUDY OF TOXICOLOGY OF TOPICALLY-APPLIED AND ENVIRONMENTAL AGENTS FOR AN IN VITRO SYSTEM TO STUDY THEIR TOXIC EFFECTS ON SKIN. THE IN VITRO SYSTEMS HAVE THE BENEFIT OF ALLOWING STUDY OF A LARGE VARIETY OF SUBSTANCES ON AN INDIVIDUAL SPECIMEN. AN IN VITRO SYSTEM CONTAINING ALL THE COMPONENTS OF SKIN ALLOWS STUDIES TO DETERMINE THE EFFECTS OF AGENTS ON THE VARIOUS C ...

    SBIR Phase I 1991 Department of Health and Human Services
  10. ORTHOTOPIC HUMAN TUMOR IMPLANTS IN NUDE MICE

    SBC: ANTICANCER, INC.            Topic: N/A

    METASTATIC RATES FROM SUBCUTANEOUS XENOGRAFTS IN NUDE MICE HAVE BEEN LOW POSSIBLY DUE TO SITE OF IMPLANTATION. THE APPROACH IS TO USE ORTHOTOPIC ONPLANATION OF INTACT TISSUE SPECIMENS RATHER THAN CULTURED CELL LINES OR DISSOCIATED TISSUE SPECIMENS. RESULTS HAVE INDICATED A HIGH TAKE RATE (SUCCESS IN 4 OF 7 PATIENT CASES) WITH DIRECT ONPLANTING TO THE COLON IN HIS LABORATORY WHERE HISTOLOGICALLY-IN ...

    SBIR Phase I 1991 Department of Health and Human Services

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