Award Data

The need for a rapid, reliable needle free delivery system for Hu BCHE bioscavengers is identified. The critical medical and design issues involved are presented. A needle free jet injection system is detailed. The Phase I effort comprises detailedpharmacokinetic studies and preliminary and detailed device design. The fabrication of a size appropriate injector for test rodents will also be underta ...

Phase II will focus on the design and development of a prototype needle-free injection system for administering BChE enzyme into humans to provide protection against chemical warfare agents. The Phase I proof-of-concept demonstrated the accelerateddelivery of BChE into the circulatory system using needle-free injection. The second phase of this project will consist of the following three tasks: ...

This Small Business Innovation Research (SBIR) Phase II project aims to develop a novel process for in-situ bioremediation of methyl tert-butyl ether (MTBE) in groundwater. The Environmental Protection Agency (EPA) considers MTBE a potential human carcinogen. Currently, MTBE's Maximum Contaminant Level (MCL) in drinking water has been set for 18 parts per billion. It is estimated that the cost of ...

This Small Business Innovation Research (SBIR) Phase I project will develop new surface derivatized reactive nanoparticles. These nanoparticles are expected to be highly active adsorbents and should be important in a number of applications. In the project, attention will be focused on preparing nanoparticles containing Lewis acid or base centers. The chemical modification involves introducing Lew ...

Surfaces Research proposes development of an innovative new extreme-temperature engine lubricant. We propose a high-temperature multicylinder engine test of the lubricant in a Surfaces Research engine operating at Future Combat System (FCS) conditions. Thenew lubricant has exceedingly long useful life at high temperature, outstanding resistance to high-temperature deposit formation, and unparallel ...

This SBIR project will develop an integrated fire modeling software package for use in building design and accident analysis. Modeling fires using a rigorous, scientific approach makes it possible to predict the course of an evolving fire and its impact on the building occupants, contents, and structure. The software will help designers implement new fire safety codes and standards that allow the ...

This Small Business Innovation Research (SBIR) Phase I project will develop a new method of measuring how strongly a thin film anchors to its substrate. To date no method exists that can truly measure thin film adhesion. The Acoustic Coaxing Induced Microcaviation (ACIM) deBonder uses controlled microcavitation to directly reveal a thin film's adhesion strength by subjecting it to controlled erosi ...

This Small Business Innovation Research Phase I project is targeted to save semiconductor wafers from being deeply scratched by unchecked large errant agglomerates in chemical mechanical planarizing or polishing (CMP) slurries. CMP has become the method of choice for restoring the surface trueness of wafers at all stages of integrated circuit manufacture. No method currently exists that can implem ...

IT IS PROPOSED TO INVESTIGATE, BY A SERIES OF EXPERIMENTS THE DESIGN OF A STORAGE AND CONTROL MECHANISM CALLED A RULING. IS A MATHEMATICAL CONCEPT WHICH LENDS ITSELD TO IMPLEMENTATION ON A CONVENTIONAL COMPUTER. IT IS AN ENVIRONMENT WHICH PERMITS LEARNING IN A REAL-TIME, UNKNOWN ENVIRONMENT, WITH CONTROL BASED ON PAST AND PRESENT LEARNED EXPERIENCE. IN A TYPICAL ENVIRONMENT, A RULING CNSUMING 10 T ...

CURRENT RAILWAYS REHABILITATION METHODS IGNORE THE PROBLEM OF SOFT, VARIABLE SUBGRADES. THE PROPOSED CAST-IN-PLACE MINIPILE SUPPORT SYSTEM "STIFFENS" THE SUBGRADE AND OFFERS AN INEXPENSIVE, VERSATILE ALTERNATIVE TO THE COSTLY, CONVENTIONAL USE OF THICKENED BALLAST SECTIONS, GROUTING, AND GEOTEXTILES. AS PROPOSED, MINIATURE CONCRETE PILES WILL BE CONSTRUCTED OFSELF-CEMENTING TYPE C FLY ASH AT VARYI ...