Award Data

DESCRIPTION (provided by applicant): A technique is proposed for the development of an intraoperative, 3-dimensional registration of C-arm fluoroscopic images with spatially-registered ultrasound visualization and implant guidance of radioactive implants and on-line implant assessment during the procedure for treatment of prostate cancer. With present techniques using transrectal ultrasound guidan ...

This Small Business Innovative Research Phase I project builds on a research program investigating the design of process-based software development tools and methodologies. The project will develop a next generation of this software that supports the creation, refinement, and adaptation of software development methodologies in a principled manner while preserving the need for rapid innovation. Th ...

The research proposed here is built on the recent successful fabrication of metal oxide semiconductor heterjunction field effect transistors (MOS-HFETs) based on AlGaN/GaN heterostructures with very high drain-current-driving and gate-control capabilitiesas well as unprecedented high breakdown voltages by the P.I.s research group at Kansas State University. III-nitride HFETs have great promises i ...

DESCRIPTION (provided by applicant): The major goal of our proposed project is to advance the development of novel compounds for the treatment of amyloidosis and other protein aggregation diseases. Preliminary work demonstrated that two chalcones inhibited amyloid fibril formation, in vitro, and that further work is warranted. The amyloid diseases that arise from nonimmunoglobulin proteins includ ...

DESCRIPTION (provided by applicant): Use of botanical products such as exogenous antioxidants has gained considerable momentum in the last few years in therapy of human degenerative diseases. Among these antioxidants, tumeric, neem, guggul, alpha-tocopherol, Beta-carotene, and ascorbic acid have been shown to have a special relevance in maintaining the redox e ...

Under Phase I effort, Applied Thin Films, Inc. (ATFI) discovered a new process to deposit oxide buffer layers for HTS coated conductors that is economical, scalable, and has demonstrated excellent performance with YBCO films (current densities of 1MA/cm2). The process is called ECONO (Epitaxial Conversion to Oxide via Nitride Oxidation) which is now being considered as the primary contender for t ...

Under Phase I effort, Applied Thin Films, Inc. (ATFI) discovered a new process to deposit oxide buffer layers for HTS coated conductors that is economical, scalable, and has demonstrated excellent performance with YBCO films (current densities of 1MA/cm2). The process is called ECONO (Epitaxial Conversion to Oxide via Nitride Oxidation) which is now being considered as the primary contender for t ...

The proposed effort relates to the use of Cerablak?, an amorphous-based black oxide material, as a coating for protection of metallic thermal protection systems (TPS) to be used in reusable launch vehicles (RLVs). This material shows potential to be a coating that meets all of NASA?s requirements for TPS protection in a single material system. The basic technical requirements for a coating to prot ...

In this Phase I SBIR project, a low-cost oxide-oxide interface coating-free ceramic matrix composite (CMC) will be developed for radomes for next-generation high speed missiles. The innovative and key component of the CMC is a newly patented matrixmaterial (CerablakT) based on aluminum phosphate compositions. The key properties of CerablakT relevant to radome applications is its low dielectric c ...

DESCRIPTION (provided by applicant): Manipulation of objects on a microscopic scale can be done conveniently with a device known as a laser or optical tweezers. While laser trapping was originally devised for trapping Rayleigh particles (i.e. particles much less than the wavelength of the incident light) it's ability to manipulate biological particles such as macromolecules, viruses, microtubul ...