Award Data

Micromachined deformable mirrors are being commercialized by the contractor and applied to DOD related projects due to their light weight, fast response, small size, and inexpensive fabrication costs. During Phase II, the contractor and university teamwill demonstrate a novel projection system incorporating a micromachined deformable mirror, and develop a complete adaptive optics system based upo ...

DESCRIPTION (provided by the applicant): Autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis, type I diabetes, and multiple sclerosis, are thought to arise from abnormalities of innate or adaptive immune responses. Autoimmune diseases are often difficult to diagnose, as the symptoms can be typical of other conditions and quite vague, such as musculoskeletal complaints ...

DESCRIPTION (provided by applicant): Autoimmune diseases are difficult to diagnose, as the symptoms can be typical of other conditions and quite vague. No currently available blood test accurately excludes or includes the possibility of an autoimmune disease in a subject, and a battery of tests and a period of observation are usually required. A single test that could readily distinguish between ...

There is a need for a low profile, simple, accurate, localized, responsive sensor to measure shear stress in fluid flow. The unusual properties of the shape memory alloy Ni2MnGa suggest it could make a very sensitive sensor. In recent years,single-crystal films of this alloy have been grown by Molecular Beam Epitaxy. Once released from their substrate, the films have exhibited shape memory beh ...

Develop a titanium, welded metal bellows extendable sunshade to deploy over seeker system optics in kinetic kill vehicles and other military missile systems that employ optical tracking. One object of the sunshade is to offer an alternative technology tohelp improve the durability of optical coatings by minimizing thermal gradients on the coatings as would be generated by free airflow across the ...

Blood loss of over 30% is a life-threatening condition. Excessive blood loss results in hemorrhagic shock (HS), which is caused by insufficient blood perfusion to vital organs. As HS persists or as additional blood is lost, vital organs fail and thepatient dies. HS causes 20% of all battlefield casualties that could otherwise be saved and, annually, 150,000 civilians in the US die from HS. In life ...

DESCRIPTION (provided by applicant): Prostate cancer is the most common malignancy in men in the United States and the second leading cause of cancer mortality. Unfortunately there is no cure by standard medical treatment. Therefore, novel treatments for this devastating, common disease are desperately needed. Recent progress in the development of targeted oncolytic viral vectors offer a new strat ...

DESCRIPTION (provided by applicant): Despite continued improvements in diagnosis, surgical techniques, and radiation protocols, the available treatments for high-grade malignant glioma are grossly inadequate. The median survival time for most patients with high-grade gliomas is on the order of months. Metastatic tumors with a tropism for the CNS such as lung and breast pose an even greater problem ...

70075T02-II Significant fuel cost savings can be realized in the automotive and aerospace industries by employing lightweight materials in the design and fabrication of vehicular components. To date, the exploitation of lightweight magnesium and aluminum alloys in component fabrication has been restricted due to their limited formability at room temperatures in conventional metal stamping proc ...

70075T02-II Significant fuel cost savings can be realized in the automotive and aerospace industries by employing lightweight materials in the design and fabrication of vehicular components. To date, the exploitation of lightweight magnesium and aluminum alloys in component fabrication has been restricted due to their limited formability at room temperatures in conventional metal stamping proc ...