Award Data

This Phase I SBIR project is directed at developing a portable, sensitive, and affordable device to detect M. tuberculosis (Mtb) in sputum samples and simultaneously determine the multidrug resistance profile of the pathogen, all within 3 days of sputum collection (It takes more than 6 weeks using current technology). By significantly reducing the time to detect viable Mtb and obtain its drug resi ...

This SBIR Phase I project will benefit society by reducing the cost of manufacturing biologic pharmaceuticals and improving their quality, including pharmaceuticals that are currently too costly to manufacture because they target relatively small patient populations. The proposed innovation will advance state-of-the-art by providing a continuous in-situ multi-analyte sensor enabling novel methods ...

This Small Business Technology Transfer Phase I project will develop advanced tools for semiconductor metrology that are essential for high accuracy at finer resolution as progress continues to the finer lithography nodes. This progress is essential to satisfy the demand for greater performance in numerous consumer products as well as many other applications. The intellectual merit of this project ...

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project will benefit nearly 6 million children per year who are suspected of having abnormal Gastroesophageal Reflux (GER) which can lead to a more serious condition with numerous complications referred to as Gastroesophageal Reflux Disease (GERD). Current detection paradigms include costly and invasi ...

This project will develop a multi-sensory therapy program for children diagnosed with Autism Spectrum Disorder by improving eye contact. Children with Autism Spectrum Disorder do not make eye contact readily and eye contact is a key component in progressing social behavior. Current methodologies to assist these children in maximizing their capabilities are out of reach for many, costing families t ...

This SBIR Phase I project will determine the feasibility of a new high risk technology for treatment of age-related macular degeneration (AMD). The technology is an AAV2-mediated concurrent expression of recombinant proteins to intracellularly suppress the critical growth factors VEGF-A (vascular endothelial growth factor A) and PDGF-B (platelet-derived growth factor) in a single injection. AMD is ...

This Small Business Innovation Research (SBIR) Phase II project will accelerate the adoption of data intensive precision agriculture, increasing yields while decreasing farm inputs such as fertilizers and pesticides. This project removes the software bottleneck (time and labor) in processing large aerial surveys taken by Unmanned Aerial Systems, enabling a cost-effective and timely process to deli ...

The broader impact/commercial potential of this project relates to the development of non-pharmacological interventions capable of improving clinical outcomes following spinal fusion surgery. Between 1998 and 2008, the annual number of spinal fusion surgeries increased 137% from 174,223 to 413,171 and the national bill for spinal fusion increased 7.9-fold. The greatest risk in spinal fusion proced ...

This Small Business Innovation Research (SBIR) Phase II project will demonstrate compatibility of a novel polytetrafluoroethylene (PTFE) composite coating with metal-polymer bearings currently on the market, scale up the coating deposition process, and implement pilot processing lines. Currently, there is a need for a method to improve adhesion at the PTFE/metal interface while also reducing corro ...

Ammonia is not only one of the most produced chemicals worldwide for fertilizer, but also a real carbon-neutral liquid fuel (CNLF), which is important for renewable energy storage and transportation. The well-known traditional Haber-Bosch (HB) process annually generates more than 120 million metric tons of ammonia for fertilizer, with about ~1.0% of the world’s annual energy consumpti ...