Award Data

This Phase I SBIR project is directed at developing a portable, sensitive, and affordable device to detect M. tuberculosis (Mtb) in sputum samples and simultaneously determine the multidrug resistance profile of the pathogen, all within 3 days of sputum collection (It takes more than 6 weeks using current technology). By significantly reducing the time to detect viable Mtb and obtain its drug resi ...

This SBIR Phase I project will benefit society by reducing the cost of manufacturing biologic pharmaceuticals and improving their quality, including pharmaceuticals that are currently too costly to manufacture because they target relatively small patient populations. The proposed innovation will advance state-of-the-art by providing a continuous in-situ multi-analyte sensor enabling novel methods ...

This Small Business Technology Transfer Phase I project will develop advanced tools for semiconductor metrology that are essential for high accuracy at finer resolution as progress continues to the finer lithography nodes. This progress is essential to satisfy the demand for greater performance in numerous consumer products as well as many other applications. The intellectual merit of this project ...

A significant problem in the automotive industry is the complexity of setting up and running Finite Element Analysis (FEA) simulations for various aspects of a design. Translating Computer-Aided Design (CAD) models to FEA models is an error-prone process commonly performed by expert users. Consequently, the FEA simulation is often relegated to the end of the design process as a “pass/fail” tes ...

There is a need for high-efficiency, radiation hard, high-temperature neutron detectors at nuclear reactor and nuclear physics facilities. Nuclear physic experiments require neutron detectors that are robust, compact, low-power, and have high-sensitivity, while stably operating in harsh environments, e.g., high-temperature and high radiation-dose. Wide-bandgap semiconductors will tolerate such env ...

Advanced modeling and simulation software, such as the Uintah Computational Framework, has been developed in the US, in part, through significant funding by the Department of Energy Office of Advanced Scientific Computing. This software, as well as similar advanced simulation software, requires expert users and high performance computing systems to effectively utilize them, which has resulted in u ...

Advances in technologies for unconventional drilling and completion of oil and gas wells have led to unprecedented production rates in the United States. In addition to evolution of directional drilling technologies and isolation methods, application of hydraulic fracturing or "fracing" has facilitated production of oil and gas from shale and other low-permeability formations. A focal point of con ...

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project will benefit nearly 6 million children per year who are suspected of having abnormal Gastroesophageal Reflux (GER) which can lead to a more serious condition with numerous complications referred to as Gastroesophageal Reflux Disease (GERD). Current detection paradigms include costly and invasi ...

This project will develop a multi-sensory therapy program for children diagnosed with Autism Spectrum Disorder by improving eye contact. Children with Autism Spectrum Disorder do not make eye contact readily and eye contact is a key component in progressing social behavior. Current methodologies to assist these children in maximizing their capabilities are out of reach for many, costing families t ...

HiFunda will develop a novel joining technology to enable integration of key technologies such as supercritical CO2 cycles that can significantly increase efficiencies and reduce power system size and cost. The technology platform developed will find application across a broad range of industrial sectors resulting in improved energy efficiency and economics for power systems based on coal and natu ...