Award Data

Intermediate and posterior uveitis cause 10% of blindness in the U.S. The mainstay of therapy is to eradicate the infectious cause and to quell the inflammation with corticosteroids or immunosuppressants. Delivery of anti-inflammatory drugs to the posteri

DESCRIPTION (provided by applicant): The long-term objective of this work is to design bi-functional peptide-drug conjugates that specifically target leukocytes. The peptide sequences are derived from ICAM-1 and bind to LFA-1 on activated leukocytes. The

The goal of this SBIR Phase II project is to bring the demonstrated Gallium Nitride (GaN) microdisplay technology to industrial maturity and to final commercialization levels. The project's goal will be accomplished by further optimizing the microdisplay device structural design and fabrication process based on the demonstrative results obtained in Phase I. Based on high-efficiency semiconductor m ...

Natural flavor compounds find wide applications in the food, feed, cosmetic, chemical and pharmaceutical industry, and isoamyl acetate is an important flavor ester. In this research program, a low-cost process is proposed to convert glucose from renewable sources to isoamyl acetate using a high-yielding metabolically engineered E coli. Isoamyl acetate produced via chemical synthesis results in an ...

DESCRIPTION (provided by applicant): A novel and promising approach for achieving bony repair especially for large bone defects is to transplant human bone marrow stromal cells or mesenchymal stem cells (hMSCs). Culture expanded hMSCs, transplanted into i

DESCRIPTION (provided by applicant): Spinal disc herniation and the resulting symptoms of intractable pain, weakness, sensory loss, incontinence and progressive arthritis are among the most common debilitating conditions back problems. When conservative t

This Small Business Innovation Research (SBIR) Phase II project is to develop a process that uses halophytic plants and aquaculture effluent to treat highly saline coal bed methane (CBM) discharge water. Vast volumes of water are a necessary though unwanted byproduct of the gas drilling process. The saline discharge is widely viewed as an environmental liability. Discharges into streams are esse ...

Small, lightweight and affordable UGVs are crucial to military physical security and homeland defense. The program will develop, demonstrate, test and deliver the Phase I JAUS compliant planning system for agile cluttered environment traversal on 2 low cost prototype UGVs. The first prototype will be based on the Omni-Directional Inspection Vehicle (ODIS) and will emphasize low-cost and ruggednes ...

The requirements currently being specified for man-packable robots far exceed the capabilities of any robots currently available. The major challenges is to satisfy both the need for all terrain mobility and long mission durations (3-6 hours) in a package between 20 and 30 lbs. Autonomous Solutions Inc. proposes to solve this dilemma through the use of a shape-shifting track that effectively pro ...

DESCRIPTION (provided by applicant): The objective of this project is to develop and test display technology that will aid anesthesiologists in diagnosing and treating unexpected events. Unexpected events occur during 30% of all anesthesia cases. Thirt