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More than 100,000 patients now receive chronic hemodialysis therapy in Medicare's End StageRenal Disease Program. Hemodialysis related amyloidosis affects a significant portion of these patients.The syndrome presents clinically as carped tunnel syndrome, cystic bone lesions, and arthropathies. Thedisorder has been identified with excessive circulating and stored quantities of Beta2-microglobulin(B ...

This proposal is in response to rapid modeling need in our military force. We plan to develop and demonstrate a framework that will allow warfighters to rapidly acquire and edit geospecific terrain databases, including both building exterior and interiors. The output of our models will be in standard 3D format, which can be used in a variety of simulation and training software, including VBS2. We ...

To address a Navy need for a high resolution full color situational awareness displays to optimize human interface for Navy personnel, ships, and crafts, Hitron Technologies Inc. proposes to develop a see-through full color transparent flexible display with collaboration of Liquid Crystal Institute of Kent State University. The transparent flexible display is based on innovative integration of a f ...

The need for the United States Navy to maintain a superior global Anti-Submarine Warfare capability is heavily dependent on sonobouys and Navy has identified a need to develop batteries to power sonobuoys which have higher power capabilities than currently used technology. Nanowise LLC proposes to develop a high power MnO2/CFx battery based on interpenetrating conductive network of nanostructures. ...

DESCRIPTION (provided by applicant): Flavonoids are ubiquitous secondary metabolites in plants with many known health benefits, which are mostly ascribed to their potent anti-oxidant activity. However, a search for novel nicotinic ligands, using high throughput pharmacological screening of a native plant extract library, and subsequently a pure flavonoid library, led to the highly surprising con ...

DESCRIPTION (provided by applicant): The dental profession has searched for many years for additional real time chair-side measures to provide objective measures to aid in the monitoring of periodontal health and early diagnosis of disease. Research efforts have produced solid evidence that constituents present in saliva can provide important complimentary diagnostic information, and have the po ...

DESCRIPTION (provided by applicant): While it has been demonstrated that gene mutations are associated with an increasing number of neurodegenerative syndromes, environmental neurotoxicants remain a key factor in the etiology of many such diseases. For example, exposure to pesticides such as maneb and paraquat increase the risk of developing Parkinson's disease. Unfortunately, there is no opt ...

DESCRIPTION (provided by applicant): Left ventricular assist device (LVAD) support allows the neonate with congenital heart disease or cardiomyopathy to grow to a larger body weight that is more feasible for complex surgical correction or heart transplant.A paracorporeal LVAD, the Berlin heart ExCor, is FDA-approved for pediatric application. Although this device is outside the body, the outflow g ...