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The proposed research program aims to develop a physics-based identification, modeling and management infrastructure for aeroelastic limit-cycle oscillations. This infrastructure will be built upon high fidelity state-of-the-art theoretical/computational methods as validated and verified by available experimental data bases, and will include (1) rapid flutter boundary determination for a wide ran ...

DESCRIPTION (provided by applicant): Treatment of alcohol use disorders (AUDs), commonly referred to as alcoholism, has been hampered by alcohol's promiscuous pharmacological effects and the complex etiology of addiction. People drink in excess for a variety of reasons, and an approach that targets more of these reasons will have greater commercial success than an approach that only targets a sole ...

DESCRIPTION (provided by applicant): Type 1 Diabetes (T1D) is an autoimmune disease that targets insulin secreting pancreatic beta cells for destruction and remains a major cause of morbidity and mortality in over 1% of the population worldwide. Although insulin therapy and islet transplantation are currently the most effective treatments, both of these approaches suffer from major limitations inc ...

DESCRIPTION (provided by applicant): The main objective of this proposal is to develop a novel cancer vaccine, ApoVax-SVN(tm) based on the use of a proprietary costimulatory chimeric ligand, 4-1BBL, designed to specifically deliver survivin, a tumor associated antigen (TAA) to professional antigen-presenting cells (APCs) and activate them for the generation of an effective anti-tumor immune respon ...

DESCRIPTION (provided by applicant): Various cancer vaccines based on tumor associated antigens (TAAs) or tumor specific antigens (TSAs) have shown efficacy in preclinical models. However, their therapeutic efficacies have been rather limited in clinical trial settings. Although the reason for clinical inefficacy for these vaccines is not known, the lack of an adjuvant with potent immunostimulato ...

Power electronic converters are essential in every MDA vehicle, with use in critical systems ranging from electric power management applications, to power distribution, to on-board servo motor/actuator drivers. Advancing state-of-the-art power electronics technologies through the use of SiC semiconductors will produce significant savings across the board in almost all areas of MDA power management ...

The objective of this Small Business Innovation Research Phase I project is to develop an isolated bi-directional ac-dc PCM-4 using a novel multi-level modular design approach compatible with silicon carbide (SiC) power switches. The multi-level PCM Module will allow for the design of power-dense, high-voltage, high-power ac-dc converters utilizing fast-switching, low-voltage power devices and hig ...

In this Small Business Innovation Research project, APEI, Inc. and TRS Technologies are partnering to develop rad-hard high density DC/DC power converters functional to temperatures in excess of 300 ºC. Expert utilization of the now emerging silicon carbide (SiC) power devices will allow for high efficiency and high junction temperature operation, leading to increased power density, reduced therm ...

In Phase I, the research team formed by APEI, Inc. and University of Arkansas proved the feasibility of developing ultra-wide temperature (-230 oC to +130 oC) motor drives utilizing silicon-germanium (SiGe) asynchronous logic digital control electronics by the successful design, simulation and layout of an insensitive-delay asynchronous microcontroller. The microcontroller incorporates asynchronou ...