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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Novel flavonoids as anti-inflammatory agents in alcoholism

    SBC: NAPROGENIX, INC.            Topic: NIAAA

    DESCRIPTION (provided by applicant): Flavonoids are ubiquitous secondary metabolites in plants with many known health benefits, which are mostly ascribed to their potent anti-oxidant activity. However, a search for novel nicotinic ligands, using high throughput pharmacological screening of a native plant extract library, and subsequently a pure flavonoid library, led to the highly surprising con ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  2. Rapid Point-of-Care Salivary Diagnostic for Periodontal Health

    SBC: INNOVATIVE DIAGNOSTICS, INC.            Topic: NIDCR

    DESCRIPTION (provided by applicant): The dental profession has searched for many years for additional real time chair-side measures to provide objective measures to aid in the monitoring of periodontal health and early diagnosis of disease. Research efforts have produced solid evidence that constituents present in saliva can provide important complimentary diagnostic information, and have the po ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  3. Novel reporter cell lines for neurotoxicant assays

    SBC: TRANSPOSAGEN BIOPHARMACEUTICALS, INC.            Topic: NIEHS

    DESCRIPTION (provided by applicant): While it has been demonstrated that gene mutations are associated with an increasing number of neurodegenerative syndromes, environmental neurotoxicants remain a key factor in the etiology of many such diseases. For example, exposure to pesticides such as maneb and paraquat increase the risk of developing Parkinson's disease. Unfortunately, there is no opt ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  4. Development of TransApical to Aorta Double Lumen Cannula for a Neonate LVAD

    SBC: W-Z BIOTECH LLC            Topic: NHLBI

    DESCRIPTION (provided by applicant): Left ventricular assist device (LVAD) support allows the neonate with congenital heart disease or cardiomyopathy to grow to a larger body weight that is more feasible for complex surgical correction or heart transplant.A paracorporeal LVAD, the Berlin heart ExCor, is FDA-approved for pediatric application. Although this device is outside the body, the outflow g ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  5. Development of SVAD System for HF Therapy

    SBC: SCR, INC.            Topic: NHLBI

    DESCRIPTION (provided by applicant): The objective of this proposal is to complete the engineering development and pre-clinical testing of the SCR SVAD system to provide partial cardiac assist in patients with less advanced stage heart failure (HF). HF isincreasing worldwide and represents a major burden in terms of health care resources and costs. Despite advances in medical care, prognosis with ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  6. Harvesting specific plant metabolites from hairy root cultures using magnetized n

    SBC: NAPROGENIX, INC.            Topic: NCCIH

    DESCRIPTION: Plants produce a wide variety of valuable bioactive metabolites, but these are commonly present in low concentrations in the wild-type plant. This makes the separation and purification of these compounds complicated and expensive. The applicant company, Naprogenix Inc, has developed a technology for increasing the yields of specific bioactive metabolites in mutant plant cell cultures ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  7. Mitochondrial Uncoupling as a Therapeutic Target in Obesity

    SBC: Nano-Mite Technologies, LLC            Topic: NIDDK

    DESCRIPTION (provided by applicant): Obesity is recognized as a national and global epidemic, as approximately 65% of adults in the United States are classified as overweight or obese as defined by body mass index (BMI). In fact, in the year 2000, the human race reached a historical landmark, when for the first time in history the number of adults with excess weight surpassed the number of those w ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  8. Transdermal Naltrexone for Opiate Addiction and Alcoholism

    SBC: ALLTRANZ, INC.            Topic: NIDA

    DESCRIPTION (provided by applicant): According to the National Survey of Drug Use and Health (NSDUH) of 2008, 7.2 million Americans are in need of treatment for Substance-Related Disorders (SRDs), and a large proportion of those need treatment for opiate pain reliever, heroin, and alcohol addiction. Naltrexone (NTX), an opioid antagonist, is currently used in oral tablet form to help maintain opio ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  9. Novel method to create knockout rats using endonucleases and spermatogonial stem

    SBC: TRANSPOSAGEN BIOPHARMACEUTICALS, INC.            Topic: 200

    DESCRIPTION provided by applicant The laboratory rat is a preferred rodent model in pre clinical drug studies Their larger size facilitates procedures otherwise difficult in mice includng studies using instrumentation blood sampling and surgeries and allows for ten times the amount of tissue collection Although rats are often more suitable than mice for pharmacological toxicological phy ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  10. Biological vector control reducing arboviruses, including Dengue and Chikungunya

    SBC: MosquitoMate, Inc            Topic: NIAID

    DESCRIPTION provided by applicant In the absence of effective approved drugs or vaccines vector control remains the only means of intervention for many against mosquito borne diseases This problem grows more complex with the recent establishment of multiple exotic mosquito species and mosquito borne pathogens Furthermore changing climate conditions are predicted to alter the traditional ra ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
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