Award Data

Triploidy offers an excellent opportunity for increased profitability and competitiveness of hatchery-based pearl farming in the U.S.-affiliated Pacific Islands and Hawaii, for little additional cost. Techniques developed in Phase I for inducing triploidy in black-lip pearl oysters (Pinctada margaritifera) using Cytochalasin B and 6-DMAP were very successful ? up to 100% in several cases. These ex ...

Triploidy offers an excellent opportunity for increased profitability and competitiveness of hatchery-based pearl farming in the U.S.-affiliated Pacific Islands and Hawaii, for little additional cost. Techniques developed in Phase I for inducing triploidy in black-lip pearl oysters (Pinctada margaritifera) using Cytochalasin B and 6-DMAP were very successful ? up to 100% in several cases. These ex ...

DESCRIPTION (provided by applicant): This proposal outlines a novel approach towards the development of a therapeutic agent to treat anthrax infection by inhibiting the intracellular actions of lethal factor, the main virulence factor expressed in Bacillus anthracis infected organisms. While antibiotics are effective in treating early-stage anthrax infection by "wild-type" Bacillus anthracis stra ...

Malaria is a tropical parasitic disease that poses a significant health threat to much of the world. Each year, approximately 500 million become infected and more them 2 million die. There is great need to control the spread of the disease. One of the main focuses of malaria vaccine development has been on the use of recombinant proteins derived from the various developmental stages of the parasit ...

DESCRIPTION (Provided by applicant): The proposed research will investigate the feasibility of utilizing inherent properties of the infection site as a means to activate antifungal prodrugs selectively. Prodrug derivatives of an antifungal agent will be prepared and tested for their susceptibility to activation by conditions present at infection sites of C. albicans. Test compounds will be analyze ...

Objectives: Phase I research demonstrated the feasibility of rotifer production and enrichment, and day 1-15 larval rearing of Asian sea bass (Lates calcarifer) at an inland hatchery site in Hawaii. The overall objective of the Phase II research and development effort will be to remove all further technical impediments to the profitable culture of Asian sea bass in Hawaii. The specific technical o ...

Objectives: Phase I research demonstrated the feasibility of rotifer production and enrichment, and day 1-15 larval rearing of Asian sea bass (Lates calcarifer) at an inland hatchery site in Hawaii. The overall objective of the Phase II research and development effort will be to remove all further technical impediments to the profitable culture of Asian sea bass in Hawaii. The specific technical o ...

HMSSS project focuses on the production of solar sea salt-leveraging sun, seawater, and wind resources-as the basis for commercial enterprises, jobs, and entrepreneurial opportunities for Molokai, an economically depressed community. The feasibility of HMSSS processes was clearly substantiated by Phase I test results, which showed that the processed products met FDA requirements. Phase II is the c ...

HMSSS project focuses on the production of solar sea salt-leveraging sun, seawater, and wind resources-as the basis for commercial enterprises, jobs, and entrepreneurial opportunities for Molokai, an economically depressed community. The feasibility of HMSSS processes was clearly substantiated by Phase I test results, which showed that the processed products met FDA requirements. Phase II is the c ...

A significant attempt is being made to establish a new vanilla industry in Hawaii. This industry will generate a new product for Hawaii and also employ displaced sugarcane employees. At present, several potential plant pathogens have been found at the new vanilla nursery. These fungi and bacteria need to be tested immediately as pathogenic species are major threats to vanilla vines. Disease-free p ...