Award Data

The broader impact/commercial potential of this Small Business Technology Transfer (STTR) Phase I project will address the need for an accessible method to identify early-stage epithelial cancers, with high accuracy, earlier and at lower cost than is currently available. In 2020, the total cost of cancer care was nearly $210 billion. Due to the nature of current cancer diagnostics, most cancers ar ...

The broader impact/commercial potential of this Small Business Technology Transfer (STTR) Phase II project is to reduce power infrastructure bottlenecks to the deployment of electric vehicle fast chargers. Typically, it is expensive to install high power electric vehicle fast chargers because of limited power availability or demand charges. A large network of electric vehicle fast chargers would r ...

The ultra-high critical magnetic fields of RE-Ba-Cu-O (REBCO RE=rare earth) High Temperature Superconductors (HTS) are very attractive for compact fusion energy systems that can operate over a temperature range of 4 – 50 K in magnetic fields beyond the realm of Nb3Sn wires. Because of the tremendous pull from compact fusion, REBCO tape supply is substantially trailing demand. 10,000 kilometers o ...

Oil and natural gas contribute 30% of the total methane (CH4) emission in the United States, CH4 is a powerful greenhouse gas that traps 87 times more radiation than carbon dioxide (CO2). Methane is often intentionally released from oil and gas wells through venting or flaring natural gas. Methane emissions occur during all phases of drilling and production, and sometimes after a well has ceased p ...

The broader / commercial impact of this Small Business Technology Transfer (STTR) Phase I project is mass production of a standardized, large-area, silicon-based materials platform (wafer) for photonic integrated circuits. Photonics is the next step in information processing, using light signals instead of electrons. Such a materials platform is expected to revolutionize the silicon photonics mark ...

Abstract Radiation induced keratopathy results in significant ocular surface disease, stem cell deficiency, vision loss, discomfort, and subsequent poor quality of life, affecting up to 23% of patients receiving radiation therapy for head and neck malignancies [1]. Studies have pointed out functional roles of corneal neurons and secretory cells of the lacrimal gland in the etiology of radiation in ...

Project Summary Choroidal neovascularization (CNV) occurs in both age-related macular degeneration (AMD) and diabetic retinopathy (DR). While anti-VEGF treatment has improved the visual outcome considerably, they are far from achieving a 100% success rate (non-responsiveness between 8 and 50%). Inherited retinal degenerations (IRDs) are a group of heterogeneous, progressive, visually debilitating ...

PROJECT SUMMARY Colorectal cancer is still a major cause of cancer-related death in the world and only a small subset of patients benefits from therapy by immune checkpoint inhibitors. Antibody–drug conjugates (ADCs) are monoclonal antibodies (mAbs) that are covalently linked to cell-killing drugs and have emerged as a major modality in anti-cancer treatment. This approach combines high specific ...

PROJECT SUMMARY Developing RNA therapeutics for rare neurodevelopmental disorders Monogenic diseases caused by mutations in single genes are individually rare, but collectively common affecting 10% of the world population. Many of these diseases are disabling or even life threatening with no available treatment. The underlying molecular mechanisms vary. Both loss of gene function and gain of toxic ...

Inflammatory bowel disease (IBD) is comprised mainly of Crohn’s Disease (CD) and Ulcerative Colitis (UC), and is characterized by a chronic non-resolving inflammatory response in the intestinal mucosa. Although the exact etiology is unknown, dysbiosis, genetic, environmental, and immunologic factors are all thought to play roles in this multifactorial disease. There are no cures, and in most cas ...